Evidence map›Paper›PMID 30852452›Full record

ArticleEnvironmental research2019

Association between prenatal particulate air pollution exposure and telomere length in cord blood: Effect modification by fetal sex.

Maria José Rosa, Hsiao-Hsien Leon Hsu, Allan C Just, Kasey J Brennan, Tessa Bloomquist, Itai Kloog, Ivan Pantic, Adriana Mercado García, Ander Wilson, Brent A Coull and 4 more

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Early-life dentine-based elemental biodynamics and cord blood telomere length.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Ambient air pollution, genetic risk and telomere length in UK biobank.Journal of exposure science & environmental epidemiology · 2024
    Article
  10. Article
  11. Article
  12. Early Environment and Telomeres: a Long-Term Toxic Relationship.Current environmental health reports · 2023
    Review
  13. Article
  14. Prenatal Exposure to Traffic-Related Air Pollution and the DNA Methylation in Cord Blood Cells: MOCEH Study.International journal of environmental research and public health · 2022
    Article
  15. Prenatal PMToxics · 2022
    Article
  16. The critical role of epigenetic mechanism in PMGenes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Maria José RosaDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: maria.rosa@mssm.edu.
Hsiao-Hsien Leon HsuDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: leon.hsu@mssm.edu.
Allan C JustDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: allan.just@mssm.edu.
Kasey J BrennanDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA. Electronic address: kb2891@cumc.columbia.edu.
Tessa BloomquistDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA. Electronic address: tb2715@cumc.columbia.edu.
Itai KloogDepartment of Geography and Environmental Development, Ben-Gurion University of the Negev, P.O.B. 653, Beer Sheva, Israel. Electronic address: ikloog@bgu.ac.il.
Ivan PanticDepartment of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico.
Adriana Mercado GarcíaCenter for Nutrition and Health Research, National Institute of Public Health, Ministry of Health, Cuernavaca, Morelos, Mexico. Electronic address: adrianam@insp.mx.
Ander WilsonDepartment of Statistics, Colorado State University, Fort Collins, CO, USA. Electronic address: ander.wilson@colostate.edu.
Brent A CoullDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: bcoull@hsph.harvard.edu.
Robert O WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: robert.wright@mssm.edu.
Martha María Téllez RojoCenter for Nutrition and Health Research, National Institute of Public Health, Ministry of Health, Cuernavaca, Morelos, Mexico. Electronic address: mmtellez@insp.mx.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA. Electronic address: ab4303@cumc.columbia.edu.
Rosalind J WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: rosalind.wright@mssm.edu.
Columbia University Irving Medical Center · USIcahn School of Medicine at Mount Sinai · USMount Sinai Hospital · USNational Institute of Public Health · SIBen-Gurion University of the Negev · ILColorado State University · USHarvard University · USInstituto Nacional de Perinatología · MX

Funding

The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2014 to 2026
$21.3M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
Metal Mixtures and NeurodevelopmentR01ES014930 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2006 to 2010
$3.2M
The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) CohortR24ES028522 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Megan K Horton, Maria Jose Rosa · 2017 to 2026
$1.8M
Prenatal Exposure to Endocrine Disrupters, DNA Methylation, and Childhood ObesityR00ES023450 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUST, ALLAN C. · 2016 to 2018
$747k
Ambient Air Pollution, Stress, Oxidative Markers and Respiratory Health in Mexican ChildrenR00ES027496 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROSA, MARIA JOSE · 2019 to 2021
$743k
Ambient Air Pollution, Stress, Oxidative Markers and Respiratory Health in Mexican ChildrenK99ES027496 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROSA, MARIA JOSE · 2017 to 2018
$207k
NIEHS NIH HHS K99 ES027496NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES023450NIEHS NIH HHS R00 ES027496NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES014930NIEHS NIH HHS R24 ES028522
6 · The paper itself

Abstract

introductionIn utero particulate matter exposure produces oxidative stress that impacts cellular processes that include telomere biology. Newborn telomere length is likely critical to an individual's telomere biology; reduction in this initial telomere setting may signal increased susceptibility to adverse outcomes later in life. We examined associations between prenatal particulate matter with diameter ≤2.5 µm (PM

methodsWomen who were residents of Mexico City and affiliated with the Mexican Social Security System were recruited during pregnancy (n = 423 for analyses). Mothers' prenatal exposure to PM

resultsIn models that included child's sex, mother's age at delivery, prenatal environmental tobacco smoke exposure, pre-pregnancy BMI, gestational age, birth season and assay batch, we found significant associations between higher PM

conclusionsIncreased PM

Indexed as

Air PollutantsAir PollutionMaternal ExposureTelomereBayes TheoremChildFemaleFetal BloodHumansInfant, NewbornMaleMexicoParticulate MatterPregnancySex FactorsAir PollutantsParticulate MatterBayesian distributed lag interaction modelsDistributive lag modelsLeukocyte telomere lengthParticulate matterPrenatal exposure

Identifiers

PMID30852452
PMCPMC6511309
OpenAlexW2919943836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.