ArticleNeuroImage. Clinical2019
Applying surface-based hippocampal morphometry to study APOE-E4 allele dose effects in cognitively unimpaired subjects.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- APOE ε4-associated hippocampal atrophy trajectories across the Alzheimer's disease continuum: a systematic review, meta-analysis, and longitudinal validation.Frontiers in aging neuroscience · 2026Pooled it
- A Systematic Review and Recommendations Around Frameworks for Evaluating Scientific Validity in Nutritional Genomics.Frontiers in nutrition · 2021Pooled it
- Alzheimer's disease prediction algorithm based on hippocampal longitudinal hybrid morphological features.Quantitative imaging in medicine and surgery · 2026Article
- APOEmedRxiv : the preprint server for health sciences · 2025Article
- MRI-Driven Longitudinal Studies of Hippocampal Alterations During the Initial Cognitive Decline.IEEE journal of translational engineering in health and medicine · 2025Article
- Interpretable discriminant analysis for functional data supported on random nonlinear domains with an application to Alzheimer's disease.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2024Article
- Combining Blood-Based Biomarkers and Structural MRI Measurements to Distinguish Persons with and without Significant Amyloid Plaques.Journal of Alzheimer's disease : JAD · 2024Article
- Correlation studies of Hippocampal Morphometry and Plasma NFL Levels in Cognitively Unimpaired Subjects.IEEE transactions on computational social systems · 2023Article
- Classification of Alzheimer's disease based on hippocampal multivariate morphometry statistics.CNS neuroscience & therapeutics · 2023Article
- Every individual makes a difference: A trinity derived from linking individual brain morphometry, connectivity and mentalising ability.Human brain mapping · 2023Article
- A Surface-Based Federated Chow Test Model for Integrating APOE Status, Tau Deposition Measure, and Hippocampal Surface Morphometry.Journal of Alzheimer's disease : JAD · 2023Article
- Improved Prediction of Amyloid-β and Tau Burden Using Hippocampal Surface Multivariate Morphometry Statistics and Sparse Coding.Journal of Alzheimer's disease : JAD · 2023Article
- APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.PLoS biology · 2022Article
- INVESTIGATING THE EFFECT OF TAU DEPOSITION AND APOE ON HIPPOCAMPAL MORPHOMETRY IN ALZHEIMER'S DISEASE: A FEDERATED CHOW TEST MODEL.Proceedings. IEEE International Symposium on Biomedical Imaging · 2022Article
- Studying APOE ɛ4 Allele Dose Effects with a Univariate Morphometry Biomarker.Journal of Alzheimer's disease : JAD · 2022Article
- An Increased Aspartate to Alanine Aminotransferase Ratio Is Associated With a Higher Risk of Cognitive Impairment.Frontiers in medicine · 2022Article
- Predicting Tau Accumulation in Cerebral Cortex with Multivariate MRI Morphometry Measurements, Sparse Coding, and Correntropy.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Multi-Resemblance Multi-Target Low-Rank Coding for Prediction of Cognitive Decline With Longitudinal Brain Images.IEEE transactions on medical imaging · 2021Article
- Predicting future cognitive decline with hyperbolic stochastic coding.Medical image analysis · 2021Article
- Predicting Brain Amyloid Using Multivariate Morphometry Statistics, Sparse Coding, and Correntropy: Validation in 1,101 Individuals From the ADNI and OASIS Databases.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
Abstract
Apolipoprotein E (APOE) e4 is the major genetic risk factor for late-onset Alzheimer's disease (AD). The dose-dependent impact of this allele on hippocampal volumes has been documented, but its influence on general hippocampal morphology in cognitively unimpaired individuals is still elusive. Capitalizing on the study of a large number of cognitively unimpaired late middle aged and older adults with two, one and no APOE-e4 alleles, the current study aims to characterize the ability of our automated surface-based hippocampal morphometry algorithm to distinguish between these three levels of genetic risk for AD and demonstrate its superiority to a commonly used hippocampal volume measurement. We examined the APOE-e4 dose effect on cross-sectional hippocampal morphology analysis in a magnetic resonance imaging (MRI) database of 117 cognitively unimpaired subjects aged between 50 and 85 years (mean = 57.4, SD = 6.3), including 36 heterozygotes (e3/e4), 37 homozygotes (e4/e4) and 44 non-carriers (e3/e3). The proposed automated framework includes hippocampal surface segmentation and reconstruction, higher-order hippocampal surface correspondence computation, and hippocampal surface deformation analysis with multivariate statistics. In our experiments, the surface-based method identified APOE-e4 dose effects on the left hippocampal morphology. Compared to the widely-used hippocampal volume measure, our hippocampal morphometry statistics showed greater statistical power by distinguishing cognitively unimpaired subjects with two, one, and no APOE-e4 alleles. Our findings mirrored previous studies showing that APOE-e4 has a dose effect on the acceleration of brain structure deformities. The results indicated that the proposed surface-based hippocampal morphometry measure is a potential preclinical AD imaging biomarker for cognitively unimpaired individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.