Trial reportJournal of anxiety disorders2019
Fear extinction learning as a predictor of response to cognitive behavioral therapy for pediatric obsessive compulsive disorder.
Trial report in Journal of anxiety disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder.Translational psychiatry · 2021Trial
- Advancements in the Assessment and Treatment of Pediatric OCD.Current psychiatry reports · 2026Review
- Shorter sleep duration predicts altered next-day physiologic, behavioral, and corticolimbic responses during fear extinction recall in youth.Neurobiology of learning and memory · 2026Article
- Enhancing the Efficacy of Exposure Therapy: Translation of Pharmacological Augmentation of Fear Extinction.Annual review of clinical psychology · 2026Review
- Are Fear Learning Processes Altered in Obsessive-Compulsive Disorder, Social Anxiety, and Specific Phobia? Insights From the Late Positive Potential, Fear-Potentiated Startle, and Ratings.Psychophysiology · 2026Article
- Using latent patient-centered fear extinction profiles to guide treatment in pediatric OCD.Psychiatry research · 2025Article
- Using pre-treatment de novo threat conditioning outcomes to predict treatment response to DCS augmentation of exposure-based CBT.Journal of psychiatric research · 2023Article
- A Psychometric Analysis of Fear of COVID-19 Scale in India.International journal of mental health and addiction · 2023Article
- Understanding clinical fear and anxiety through the lens of human fear conditioning.Nature reviews psychology · 2023Review
- Getting Better with Age? A Review of Psychophysiological Studies of Fear Extinction Learning Across Development.Current topics in behavioral neurosciences · 2023Review
- Is Fear Extinction Impairment Central to Psychopathology?Current topics in behavioral neurosciences · 2023Article
- Behavioral Activation as a Principle-Based Treatment: Developments from a Multi-Site Collaboration to Advance Adolescent Depression Treatment.Evidence-based practice in child and adolescent mental health · 2023Article
- Mechanisms of exposure and response prevention in obsessive-compulsive disorder: effects of habituation and expectancy violation on short-term outcome in cognitive behavioral therapy.BMC psychiatry · 2022Article
- Internet-based cognitive behavioral therapy in children and adolescents with obsessive compulsive disorder: a feasibility study.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Pavlovian Learning Processes in Pediatric Anxiety Disorders: A Critical Review.Biological psychiatry · 2021Review
- Effects of Treatment Setting on Outcomes of Flexibly-Dosed Intensive Cognitive Behavioral Therapy for Pediatric OCD: A Randomized Controlled Pilot Trial.Frontiers in psychiatry · 2021Article
- Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder.The American journal of psychiatry · 2021Review
- Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors.Behavioural brain research · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundWhile cognitive behavior therapy (CBT) is an effective treatment for many children and adolescents with Obsessive Compulsive Disorder (OCD), therapeutic response is variable. Fear conditioning and extinction are central constructs underlying exposure-based CBT. Fear extinction learning assessed prior to CBT may be a useful predictor of CBT response for guiding treatment decisions.
methodsSixty-four youth who participated in a randomized placebo-controlled trial of CBT with and without d-cycloserine (DCS) completed a fear conditioning task. Skin conductance response (SCR) scores were used to measure fear acquisition and extinction to determine whether extinction learning could predict CBT response.
resultsCBT responders and non-responders appeared to acquire conditioned fear SCRs in a similar manner. However, differences between treatment responders and non-responders emerged during the extinction phase. A responder (responder, non-responder) by conditioned stimulus type (CS+, CS-) interaction showed that CBT responders differentiated the stimulus paired with (CS+) and without (CS-) the unconditioned stimulus correctly during early and late extinction, whereas the CBT non-responders did not (p = .004).
conclusionsWhile the small sample size makes conclusions tentative, this study supports an emerging literature that differential fear extinction may be an important factor underlying clinical correlates of pediatric OCD, including CBT response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.