ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Association Between Duration of Untreated Psychosis and Frontostriatal Connectivity During Maintenance of Visuospatial Working Memory.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spontaneous Brain Activity Alterations in First-Episode Psychosis: A Meta-analysis of Functional Magnetic Resonance Imaging Studies.Schizophrenia bulletin · 2023Pooled it
- Effect of mGluR2 positive allosteric modulation on frontostriatal working memory activation in schizophrenia.Molecular psychiatry · 2022Trial
- Mind the delay: duration of untreated psychosis is associated with short-term outcomes in first-episode schizophrenia.Frontiers in psychiatry · 2026Article
- Duration of Untreated Psychosis, Treatment Response, and Resting State Functional Connectivity in Antipsychotic-Naïve First-Episode Psychosis Patients.Schizophrenia bulletin open · 2026Article
- The neurobiology of duration of untreated psychosis: a comprehensive review.Molecular psychiatry · 2023Review
- Load-dependent functional connectivity deficits during visual working memory in first-episode psychosis.Journal of psychiatric research · 2022Article
- Context-specific abnormalities of the central executive network in first-episode psychosis: relationship with cognition.Psychological medicine · 2022Article
- Changes in corticostriatal connectivity and striatal tissue iron associated with efficacy of clozapine for treatment‑resistant schizophrenia.Psychopharmacology · 2022Article
- Functional Connectivity During Visuospatial Processing in Schizophrenia: A Classification Study Using Lasso Regression.Neuropsychiatric disease and treatment · 2021Article
- Aberrant static and dynamic functional patterns of frontoparietal control network in antipsychotic-naïve first-episode psychosis subjects.Human brain mapping · 2020Article
- Duration of Untreated Psychosis Correlates With Brain Connectivity and Morphology in Medication-Naïve Patients With First-Episode Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Increased Functional Coupling between VTA and Hippocampus during Rest in First-Episode Psychosis.eNeuroArticle
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Abstract
backgroundA longer duration of untreated psychosis (DUP) has been linked with poor clinical outcomes and variation in resting-state striatal connectivity with central executive regions. However, the link between DUP and task-based activation of executive neurocognition has not previously been examined. This functional magnetic resonance imaging study examined the association between DUP and both activation and frontostriatal functional connectivity during a visual working memory (WM) paradigm in patients with first-episode psychosis.
methodsPatients with first-episode psychosis (n = 37) underwent functional magnetic resonance imaging scanning while performing a visual WM task. At the single-subject level, task conditions were modeled; at the group level, each condition was examined along with DUP. Activation was examined within the dorsolateral prefrontal cortex, a primary region supporting visual WM activation. Frontostriatal functional connectivity during the WM was examined via psychophysical interaction between the dorsal caudate and the dorsolateral prefrontal cortex. Results were compared with a reference range of connectivity values in a matched group of healthy volunteers (n = 25). Task performance was also examined in relation to neuroimaging findings.
resultsNo significant association was observed between DUP and WM activation. Longer DUP showed less functional frontostriatal connectivity with the maintenance of increasing WM load. Results were not related to task performance measures, consistent with previous work.
conclusionsOur data suggest that DUP may affect frontostriatal circuitry that supports executive functioning. Future work is necessary to examine if these findings contribute to the mechanism underlying the relationship between DUP and worsened clinical outcomes.
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