Evidence map›Paper›PMID 30851630›Full record

ArticleThrombosis research2019

Enhanced potency of prasugrel on protease-activated receptors following bivalirudin treatment for PCI as compared to clopidogrel.

Carey Kimmelstiel, Ryan Stevenson, Nga Nguyen, Layla Van Doren, Ping Zhang, James Perkins, Navin K Kapur, Andrew Weintraub, Vilma Castaneda, Athan Kuliopulos and 1 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in Thrombosis research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Carey KimmelstielCardiac Catheterization Laboratory and the Division of Cardiology, Tufts Medical Center, Boston, MA 02111, United States of America.
Ryan StevensonHemostasis and Thrombosis Laboratory, Division of Hematology/Oncology, Tufts Medical Center, Boston, MA 02111, United States of America.
Nga NguyenHemostasis and Thrombosis Laboratory, Division of Hematology/Oncology, Tufts Medical Center, Boston, MA 02111, United States of America.
Layla Van DorenHemostasis and Thrombosis Laboratory, Division of Hematology/Oncology, Tufts Medical Center, Boston, MA 02111, United States of America.
Ping ZhangHemostasis and Thrombosis Laboratory, Division of Hematology/Oncology, Tufts Medical Center, Boston, MA 02111, United States of America.
James PerkinsHemostasis and Thrombosis Laboratory, Division of Hematology/Oncology, Tufts Medical Center, Boston, MA 02111, United States of America.
Navin K KapurCardiac Catheterization Laboratory and the Division of Cardiology, Tufts Medical Center, Boston, MA 02111, United States of America.
Andrew WeintraubCardiac Catheterization Laboratory and the Division of Cardiology, Tufts Medical Center, Boston, MA 02111, United States of America.
Vilma CastanedaCardiac Catheterization Laboratory and the Division of Cardiology, Tufts Medical Center, Boston, MA 02111, United States of America.
Athan KuliopulosHemostasis and Thrombosis Laboratory, Division of Hematology/Oncology, Tufts Medical Center, Boston, MA 02111, United States of America.
Lidija CovicHemostasis and Thrombosis Laboratory, Division of Hematology/Oncology, Tufts Medical Center, Boston, MA 02111, United States of America. Electronic address: lcovic@tuftsmedicalcenter.org.
Tufts Medical Center · US

Funding

TRIP-PCI: PAR1 Pepducin-Based Interventions in Arterial ThrombosisP50HL110789 · NHLBI · TUFTS MEDICAL CENTER · PI KULIOPULOS, ATHAN · 2012 to 2016
$10.0M
Matrix Metalloprotease-PAR1 Regulation of AtherosclerosisR01HL136485 · NHLBI · TUFTS MEDICAL CENTER · PI KULIOPULOS, ATHAN · 2018 to 2021
$2.8M
Protease Activated Receptors in Cancer InvasionR01CA104406 · NCI · TUFTS MEDICAL CENTER · PI COVIC, LIDIJA · 2005 to 2009
$1.6M
NCI NIH HHS R01 CA104406NHLBI NIH HHS P50 HL110789NHLBI NIH HHS R01 HL136485
6 · The paper itself

Abstract

ACS patients undergoing percutaneous coronary intervention (PCI) when treated with bivalirudin and clopidogrel had increased frequency of early stent thrombosis. 24 patients referred for intervention with planned bivalirudin therapy, not previously treated with a P2Y

Indexed as

Percutaneous Coronary InterventionAgedAntithrombinsFemaleHirudinsHumansMaleMiddle AgedPeptide FragmentsPlatelet Aggregation InhibitorsPrasugrel HydrochlorideReceptors, Purinergic P2Y12Receptors, ThrombinRecombinant ProteinsStentsThrombosisAntithrombinsbivalirudinHirudinsPeptide FragmentsPlatelet Aggregation InhibitorsPrasugrel Hydrochlorideprotease-activated receptor 4Receptors, Purinergic P2Y12Receptors, ThrombinRecombinant ProteinsArterial thrombosisCollagenP2Y(12)PAR4 SNP rs773902Platelets

Identifiers

PMID30851630
PMCPMC6820131
OpenAlexW2912241999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.