ArticlePapillomavirus research (Amsterdam, Netherlands)2019
Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia.
Article in Papillomavirus research (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Effects of human papillomavirus (HPV) vaccination programmes on community rates of HPV-related disease and harms from vaccination.The Cochrane database of systematic reviews · 2025Pooled it
- Detection and natural history of HPV infection of oral cavity and tonsils - a systematic literature review.BMC cancer · 2025Pooled it
- The Effect of Prophylactic HPV Vaccines on Oral and Oropharyngeal HPV Infection-A Systematic Review.Viruses · 2021Pooled it
- Human papillomavirus (HPV) vaccines in adults: Learnings from long-term follow-up of quadrivalent HPV vaccine clinical trials.Human vaccines & immunotherapeutics · 2023Trial
- Simple and efficient co-synthesis of gold nanoparticles and nanoclusters for HPV-16 detection.Scientific reports · 2026Article
- Human papillomavirus (HPV) related oropharyngeal cancers in Canada: A multicenter retrospective cohort study.Human vaccines & immunotherapeutics · 2025Article
- Human Papillomavirus-Related Cancer Vaccine Strategies.Vaccines · 2024Review
- The effectiveness of HPV vaccination on the incidence of oropharyngeal cancers in men: a review.Infectious agents and cancer · 2023Review
- Impact of HPV vaccination on HPV-related oral infections.Oral oncology · 2023Article
- Sequential acquisition of human papillomavirus infection between genital and oral anatomic sites in males.International journal of cancer · 2021Article
- Cancer epidemiology in Cali, 60 years of experience.Colombia medica (Cali, Colombia)Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionIn recent years, an association between HPV-16 and oropharyngeal cancers has been reported. Therefore, it is necessary to evaluate whether vaccination decreases the exposure of HPV-16 in the oral cavity.
objectiveTo evaluate the effect of vaccination on oral HPV-16 infection in high school students in the city of Cali, Colombia.
methodsIn this cross-sectional study, HPV-16 DNA was detected in samples from the oral cavity and throat of 1,784 high school students of both genders, aged 14-17 years old, in 21 schools in the city of Cali, Colombia. The number in vaccinated girls were 944 vs., 95 unvaccinated girls and 745 unvaccinated boys.
resultsThe HPV exposure percentages were: 0.7% in vaccinated girls, 3.2% in unvaccinated girls and 2.3% in unvaccinated boys. The odds ratio (OR) of detection of HPV-16 in vaccinated versus unvaccinated students was 0.28 (95% CI: 0.07-0.88), representing a 72% reduction in HPV-16 detection in students immunized with two doses. The odds of detection of HPV-16 in unvaccinated male students were 3.6 times those of vaccinated girls (OR = 3.6, 95% CI: 1.21-12.81) and increased to almost eight-fold in boys who had initiated sexual activity (OR = 7.74, 95% CI: 1.53-75.09).
conclusionsHPV vaccination was associated with the reduction of HPV-16 exposure percentages in the oral and oropharyngeal cavity.
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Registered trials
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