Evidence map›Paper›PMID 30851397›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2020

Parent-Based Treatment as Efficacious as Cognitive-Behavioral Therapy for Childhood Anxiety: A Randomized Noninferiority Study of Supportive Parenting for Anxious Childhood Emotions.

Eli R Lebowitz, Carla Marin, Alyssa Martino, Yaara Shimshoni, Wendy K Silverman

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 108 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 11 pooled it
34.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02310152 nacompletednot on this map

Explanatory Clinical Trial of a Novel Parent Intervention for Childhood Anxiety (SPACE)

TypeinterventionalSponsorYale UniversityRan2014 to 2018Enrolled124ConditionsAnxiety Disorders, Anxiety, Separation, Phobic DisordersArmsParent-Based Treatment of Child and Adolescent Anxiety Disorders, CBT
NCT06352463 narecruitingnot on this mapstarted 2024, after this paper: background citation

More Than the Sum of Its Parts: Investigating a Combined Parent-child Treatment for Children With Social Anxiety

TypeinterventionalSponsorLeiden UniversityRan2024 to 2025Enrolled9ConditionsSocial Anxiety Disorder of ChildhoodArmsDenken + Doen = Durven, Supportive Parenting for Anxious Childhood Emotions
NCT06356090 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Supportive Parenting for Anxious Childhood Emotions (SPACE): an Innovative Parent-based Treatment for Children With Obsessive-compulsive Disorder

TypeinterventionalSponsorChaim HuijserRan2023 to 2025Enrolled25ConditionsObsessive-Compulsive Disorder, Obsessive-Compulsive Disorder in Children, Obsessive-Compulsive Disorder in Adolescence, Anxiety Disorders and SymptomsArmsSupportive Parenting for Anxious Childhood Emotions (SPACE)
3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 11 syntheses or guidelines pooled it, 248 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Behavioral interventions for infant sleep problems: the role of parental cry tolerance and sleep-related cognitions.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Trial
  18. Technology-Enhanced BPT for Early-Onset Behavior Disorders: Improved Outcomes for Children With Co-Occurring Internalizing Symptoms.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Trial
  19. Parent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Trial
  20. Oxytocin as a Biomarker of Differential Effects to SPACE vs. CBT Treatment of Child Anxiety Disorders.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Trial

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eli R LebowitzYale University Child Study Center, New Haven, CT. Electronic address: eli.lebowitz@yale.edu.
Carla MarinYale University Child Study Center, New Haven, CT.
Alyssa MartinoYale University Child Study Center, New Haven, CT.
Yaara ShimshoniYale University Child Study Center, New Haven, CT.
Wendy K SilvermanYale University Child Study Center, New Haven, CT.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Yale University Clinical and Translational Science Award ProgramKL2TR000140 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$2.9M
Explanatory Clinical Trial of a Novel Parent Intervention for Childhood AnxietyK23MH103555 · NIMH · YALE UNIVERSITY · PI LEBOWITZ, ELI · 2014 to 2017
$703k
Fibroblast Growth Factor 2's role in Fear and Approach Motivation in Anxious and Depressed Children and their MothersR21MH113946 · NIMH · YALE UNIVERSITY · PI LEBOWITZ, ELI, SILVERMAN, WENDY K. · 2017 to 2018
$461k
NCATS NIH HHS KL2 TR000140NCATS NIH HHS KL2 TR001862NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH103555NIMH NIH HHS R21 MH113946
6 · The paper itself

Abstract

objectiveTreatment for childhood anxiety disorders is insufficient in many cases. Parent involvement has been examined to augment child-based cognitive-behavioral therapy (CBT), but no studies have compared the efficacy of stand-alone parent-based treatment to CBT. Research implicates family accommodation in the maintenance and course of childhood anxiety. Supportive Parenting for Anxious Childhood Emotions (SPACE) is a parent-based treatment that reduces accommodation of childhood anxiety. This study compared SPACE to CBT in a noninferiority trial.

methodParticipants were children with primary anxiety disorders (N = 124; 7-14 years of age; 53% female participants; 83% white), randomly assigned to either SPACE (n = 64) with no direct child-therapist contact, or CBT (n = 60) with no parent treatment. A total of 97 participants (78%) completed all treatment sessions and assessments. Attrition did not differ significantly between groups. Primary anxiety outcomes included diagnostic interview and clinician-rated scales. Secondary outcomes included parent and child ratings of anxiety severity, family accommodation, and parenting stress. Noninferiority margins were determined based on statistical and clinical considerations. Change in family accommodation and parenting stress were examined using mixed models analyses.

resultsSPACE was noninferior, relative to CBT, on primary and secondary anxiety outcomes, and based on ratings provided by independent evaluators, parents, and children. Family accommodation and parenting stress were significantly reduced in both treatments, with significantly greater reduction in family accommodation following SPACE compared to CBT. Treatment credibility and satisfaction were high.

conclusionSPACE is an acceptable and efficacious treatment for childhood anxiety disorders, is noninferior to CBT, and provides an alternative strategy for treating anxiety in children. CLINICAL TRIAL REGISTRATION INFORMATION: Explanatory Clinical Trial of a Novel Parent Intervention for Childhood Anxiety (SPACE); https://clinicaltrials.gov; NCT02310152.

Indexed as

Cognitive Behavioral TherapyParentingAnxietyAnxiety DisordersChildCognitionFemaleHumansMaleMiddle AgedTreatment Outcomeanxiety disorderscognitive-behavioral therapy clinical trialsfamily accommodationparent-based treatment

Identifiers

PMID30851397
PMCPMC6732048
OpenAlexW2921567862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.