ArticleBrain, behavior, and immunity2019
Depressive symptoms and immune transcriptional profiles in late adolescents.
Article in Brain, behavior, and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Inflammation and depression in young people: a systematic review and proposed inflammatory pathways.Molecular psychiatry · 2022Pooled it
- Interpersonal stress, epigenetic indices of inflammation, and depressive symptoms: Longitudinal associations from adolescence to young adulthood.Neurobiology of stress · 2026Article
- Optimization of potential targets for antidepressant Chinese medicines: AI and multi-omics methods.Chinese medicine · 2026Review
- Psychological stress and social support are associated with opposing single-cell pro-inflammatory gene regulatory mechanisms in adults.bioRxiv : the preprint server for biology · 2025Article
- Nuclear factor kappa-B cell (NF-κB), interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection.Brain, behavior, and immunity · 2025Article
- Transcriptomic analysis reveals potential crosstalk genes and immune relationship between triple-negative breast cancer and depression.Discover oncology · 2024Article
- A Selective Nuclear Factor-κB Inhibitor, JSH-23, Exhibits Antidepressant-like Effects and Reduces Brain Inflammation in Rats.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Inflammation and immune system pathways as biological signatures of adolescent depression-the IDEA-RiSCo study.Translational psychiatry · 2024Article
- Chronic Treatment withInternational journal of molecular sciences · 2024Article
- Maternal immune activation upregulates the AU020206-IRFs-STAT1 axis in modulating cytokine production in the brain.Theranostics · 2024Article
- Depressive symptoms and all-cause mortality among middle-aged and older people in China and associations with chronic diseases.Frontiers in public health · 2024Article
- Graves' disease as a driver of depression: a mechanistic insight.Frontiers in endocrinology · 2023Review
- Identification of common genetic characteristics of rheumatoid arthritis and major depressive disorder by bioinformatics analysis and machine learning.Frontiers in immunology · 2023Article
- Review
- Gene expression study in monocytes: evidence of inflammatory dysregulation in early-onset obsessive-compulsive disorder.Translational psychiatry · 2022Article
- Evaluation of Inflammatory Response System (IRS) and Compensatory Immune Response System (CIRS) in Adolescent Major Depression.Journal of inflammation research · 2022Article
- Preventive strategies for adolescent depression: What are we missing? A focus on biomarkers.Brain, behavior, & immunity - health · 2021Article
- Study of Post-COVID-19 Syndrome in Saudi Arabia.Cureus · 2021Article
- Evaluating the Relationship Between Depression and Cognitive Function Among Children and Adolescents with HIV in Zambia.AIDS and behavior · 2021Article
- miR-218 in Adolescence Predicts and Mediates Vulnerability to Stress.Biological psychiatry · 2021Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRates of depression increase and peak during late adolescence and alterations in immune processes are thought to be both a risk factor and outcome of depression. However, few studies have examined depression-immune dynamics among adolescents. Using a functional genomics approach, the current study examined whether depressive symptoms were associated with activation of a gene expression profile, characterized by upregulated expression of pro-inflammatory-related genes and downregulated expression of antiviral-related genes in a sample of older adolescents (M
methodParticipants (n = 87) reported on their depressive symptoms during the past week using the CES-D, and provided blood samples for genome-wide transcriptional profiling of mRNA.
resultsAdolescents with clinically-significant levels of depressive symptoms (CES-D ≥ 16) exhibited upregulated expression of inflammation-related genes and downregulated expression of antiviral-related genes compared to their peers with lower levels of depressive symptoms (CES-D < 16). Bioinformatics analyses suggested that this pattern of differential gene expression was mediated by greater activity of the pro-inflammatory transcription factor, nuclear factor-kappa B (NF-κB), and reduced activity of glucocorticoid receptors (GRs) and interferon response factors (IRFs). Additional analyses implicated monocytes, B cells, and dendritic cells as primary cellular sources of the observed gene expression patterns associated with depressive symptoms.
conclusionResults are consistent with past work demonstrating links between depression and altered immunity. They provide a molecular basis for these associations and suggest that the underlying molecular signature may emerge as early as late adolescence when rates of depression tend to increase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.