ArticleImmunity, inflammation and disease2019
Reduction of active Fel d1 from cats using an antiFel d1 egg IgY antibody.
Article in Immunity, inflammation and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Human Allergy to Cats and Dogs: Molecular and Environmental Determinants, Diagnosis, and Precision Management.Veterinary sciences · 2026Review
- Engineering Epitope-Specific IgY Antibodies to Neutralize the Major Fel d 1 Allergen in Cats.International journal of molecular sciences · 2026Article
- Taming pet allergens: strategies to make furry cats less allergenic.Frontiers in allergy · 2026Review
- Advance in Managing Indoor Cat Allergen Proteins: Molecular Insights, Detection, and Control.International journal of molecular sciences · 2025Review
- Innovative Strategies to Reduce Exposure and Expression of the Major Cat Allergen Fel d 1.Clinical and translational allergy · 2025Review
- Review
- Proof-of-concept study of anti-Fel d 1 IgY antibodies in cat food using the MASK-airClinical and translational allergy · 2024Article
- Evaluation of anti-Fel d 1 IgY ingredient for pet food on growth performance in kittens.Frontiers in veterinary science · 2024Article
- The holo beta-lactoglobulin lozenge reduces symptoms in cat allergy-Evaluation in an allergen exposure chamber and by titrated nasal allergen challenge.Clinical and translational allergy · 2023Article
- IgY Antibodies as Biotherapeutics in Biomedicine.Antibodies (Basel, Switzerland) · 2022Review
- Human allergy to cats: A review of the impact on cat ownership and relinquishment.Journal of feline medicine and surgery · 2022Review
- Human allergy to cats: A review for veterinarians on prevalence, causes, symptoms and control.Journal of feline medicine and surgery · 2022Review
- Molecular diagnosis in cat allergy.World journal of methodology · 2021Review
- New Frontiers: Precise Editing of Allergen Genes Using CRISPR.Frontiers in allergy · 2021Review
- Hello, kitty: could cat allergy be a form of intoxication?The journal of venomous animals and toxins including tropical diseases · 2020Article
- The race to deliver the hypoallergenic cat.Nature · 2020Article
- Article
- The Major Cat Allergen Fel d 1 Binds Steroid and Fatty Acid Semiochemicals: A Combined In Silico and In Vitro Study.International journal of molecular sciences · 2020Article
- Article
- Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen.Allergy · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFel d1 is the most important allergen from cats. Fel d1 is produced primarily in saliva and spread to the haircoat during grooming and then transferred to the environment via hair and dander.
objectivesA novel approach to reducing allergenic Fel d1 exposure was evaluated, involving binding the Fel d1 with an anti-Fel d1 polyclonal egg IgY antibody. The hypothesis was that hair from cats who had been fed foods containing anti-Fel d1 IgY would show a significant reduction in active Fel d1 (aFel d1).
methodsHair collected from 105 cats completing a 12-week study was evaluated for aFel d1 via ELISA. Hair was collected four times over a 2-week baseline period, then weekly during the 10 week treatment period during which cats consumed a food containing the anti-Fel d1 IgY.
resultsBaseline aFel d1 (μg/g hair) varied greatly among the cats in this study. From week 3, there was a significant reduction in mean aFel d1 with an overall average decrease of 47% by week 10, ranging from a 33-71% decrease vs baseline. Cats with the highest baseline aFel d1 showed the greatest decrease in aFel d1. CONCLUSIONS & CLINICAL IMPLICATIONS: Feeding anti-Fel d1 IgY to cats successfully reduced aFel d1 on their haircoat with the greatest decreases observed in cats with initially high levels. Feeding a diet with anti Fel d1 IgY significantly reduced the active Fel d1 on the hair of cats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.