Trial reportJournal of periodontal research2019
No differences in microbiome changes between anti-adhesive and antibacterial ingredients in toothpastes during periodontal therapy.
Trial report in Journal of periodontal research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2021Pooled it
- Comparison of new formulas of stannous fluoride toothpastes with other commercially available fluoridated toothpastes: A systematic review and meta-analysis of randomised controlled trials.International dental journal · 2020Pooled it
- Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial.Scientific reports · 2021Trial
- No differences in microbiome changes between anti-adhesive and antibacterial ingredients in toothpastes during periodontal therapy.Journal of periodontal research · 2019Trial
- Oral Microbiome Signatures in Indonesian Healthy, Gingivitis, and Periodontitis Subjects: A 16S rRNA Next-Generation Sequencing Analysis-Based Exploratory Study.Dentistry journal · 2026Article
- Exhaled Carbon Monoxide Indicates Persistent Subgingival Dysbiosis After Periodontal Therapy.Journal of clinical periodontology · 2026Article
- Stannous Fluoride in Toothpastes: A Review of Its Clinical Effects and Likely Mechanisms of Action.Journal of functional biomaterials · 2025Review
- Association of supragingival plaque management with subgingival microbiota is moderated by adjunctive antibiotics in stage III-IV periodontitis patients during periodontal therapy.Journal of oral microbiology · 2025Article
- Systematic Review of Zinc's Benefits and Biological Effects on Oral Health.Materials (Basel, Switzerland) · 2024Review
- Effect of Periodontal Interventions on Characteristics of the Periodontal Microbial Profile: A Systematic Review and Meta-Analysis.Microorganisms · 2022Article
- Hydroxyapatite in Oral Care Products-A Review.Materials (Basel, Switzerland) · 2021Review
- Metagenomic and Metatranscriptomic Insight Into Oral Biofilms in Periodontitis and Related Systemic Diseases.Frontiers in microbiology · 2021Review
- Whitening Effects of a Novel Oral Care Gel with Biomimetic Hydroxyapatite: A 4-Week Observational Pilot Study.Biomimetics (Basel, Switzerland) · 2020Article
- Stannous Fluoride Effects on Enamel: A Systematic Review.Biomimetics (Basel, Switzerland) · 2020Review
- In Vitro Whitening Effect of a Hydroxyapatite-Based Oral Care Gel.European journal of dentistry · 2020Article
- Daily Application of a Toothpaste with Biomimetic Hydroxyapatite and Its Subjective Impact on Dentin Hypersensitivity, Tooth Smoothness, Tooth Whitening, Gum Bleeding, and Feeling of Freshness.Biomimetics (Basel, Switzerland) · 2020Article
- In Vivo Effects of a Hydroxyapatite-Based Oral Care Gel on the Calcium and Phosphorus Levels of Dental Plaque.European journal of dentistry · 2020Article
- Significant Short-Term Shifts in the Microbiomes of Smokers With Periodontitis After Periodontal Therapy With Amoxicillin & Metronidazole as Revealed by 16S rDNA Amplicon Next Generation Sequencing.Frontiers in cellular and infection microbiology · 2020Article
- A Critical Review of Modern Concepts for Teeth Whitening.Dentistry journal · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
aimThis subgroup analysis of a 12-week randomized, double-blind, and two-center trial aimed to evaluate whether two different toothpaste formulations can differentially modulate the dental microbiome. MATERIAL AND
methodsForty one mild to moderate periodontitis patients used as an adjunct to periodontal treatment either a toothpaste with anti-adhesive zinc-substituted carbonated hydroxyapatite (HA) or with antimicrobial and anti-adhesive amine fluoride/stannous fluoride (AmF/SnF
resultsInterproximal and subgingival sites harbored predominately Fusobacterium and Prevotella species associated with periodontitis, whereas buccal/lingual sites harbored mainly Streptococcus and Veillonella species associated with periodontal health. Alpha and beta diversity did not change noticeably differently between both toothpaste groups (P > 0.05, ANCOVA). Furthermore, none of the aRSVs showed a noticeably different change between the tested toothpastes during periodontal therapy (P
conclusionThe use of a toothpaste containing anti-adhesive HA did not induce statistically noticeably different changes on microbial composition compared to an antimicrobial and anti-adhesive AmF/SnF
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.