Evidence map›Paper›PMID 30850972›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

Impact of the 2'- and 3'-Sugar Hydroxyl Moieties on Gas-Phase Nucleoside Structure.

L A Hamlow, Zachary J Devereaux, H A Roy, N A Cunningham, G Berden, J Oomens, M T Rodgers

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

L A HamlowDepartment of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI, 48202, USA.
Zachary J DevereauxDepartment of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI, 48202, USA.
H A RoyDepartment of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI, 48202, USA.
N A CunninghamDepartment of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI, 48202, USA.
G BerdenInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, Toernooiveld 7c, 6525ED, Nijmegen, The Netherlands.
J OomensInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, Toernooiveld 7c, 6525ED, Nijmegen, The Netherlands.
M T RodgersDepartment of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI, 48202, USA. mrodgers@chem.wayne.edu.ORCID http://orcid.org/0000-0002-5614-0948
Wayne State University · USRadboud University Nijmegen · NL

Funding

Directorate for Mathematical and Physical Sciences CHE-01709789Division of Biological Infrastructure DBI-0922819Division of Graduate Education OISE-1357887
6 · The paper itself

Abstract

Modified nucleosides have been an important target for pharmaceutical development for the treatment of cancer, herpes simplex virus, and the human immunodeficiency virus (HIV). Amongst these nucleoside analogues, those based on 2',3'-dideoxyribose sugars are quite common, particularly in anti-HIV applications. The gas-phase structures of several protonated 2',3'-dideoxyribose nucleosides are examined in this work and compared with those of the analogous protonated DNA, RNA, and arabinose nucleosides to elucidate the influence of the 2'- and combined 2',3'-hydroxyl groups on intrinsic structure. Infrared multiple photon dissociation (IRMPD) action spectra are collected for the protonated 2',3'-dideoxy forms of adenosine, guanosine, cytidine, thymidine and uridine, [ddAdo+H]

Indexed as

Antiviral AgentsArabinoseDeoxyriboseFourier AnalysisHydroxyl RadicalInfrared RaysMass SpectrometryModels, MolecularMolecular ConformationNucleosidesProtonsPurinesPyrimidinesAntiviral AgentsArabinoseDeoxyriboseHydroxyl RadicalNucleosidesProtonsPurinesPyrimidines2′,3′-Dideoxyadenosine2′,3′-Dideoxycytidine2′,3′-Dideoxyguanosine2′,3′-Dideoxythymidine2′,3′-DideoxyuridineComputational chemistryInfrared multiple photon dissociation action spectroscopyIRMPD

Identifiers

PMID30850972
OpenAlexW2921161034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.