ArticleScientific reports2019
Similarities, variations, and evolution of cytochrome P450s in Streptomyces versus Mycobacterium.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Pezizomycetes Genomes Reveal Diverse P450 Complements Characteristic of Saprotrophic and Ectomycorrhizal Lifestyles.Journal of fungi (Basel, Switzerland) · 2023Article
- Evolution of Cytochrome P450 Enzymes and Their Redox Partners in Archaea.International journal of molecular sciences · 2023Article
- Cytochromes P450 involved in bacterial RiPP biosyntheses.Journal of industrial microbiology & biotechnology · 2023Review
- Evolutionary pathways for deep-sea adaptation in marine planktonicFrontiers in microbiology · 2023Article
- Article
- Saprophytic to Pathogenic Mycobacteria: Loss of Cytochrome P450s Vis a Vis Their Prominent Involvement in Natural Metabolite Biosynthesis.International journal of molecular sciences · 2022Article
- Lifestyles Shape the Cytochrome P450 Repertoire of the Bacterial PhylumInternational journal of molecular sciences · 2022Article
- Contrasting Health Effects ofInternational journal of molecular sciences · 2022Article
- An Unprecedented Number of Cytochrome P450s Are Involved in Secondary Metabolism inMicroorganisms · 2022Article
- Ancient Bacterial ClassInternational journal of molecular sciences · 2021Article
- In Silico Analysis of P450s and Their Role in Secondary Metabolism in the Bacterial ClassMolecules (Basel, Switzerland) · 2021Article
- Impact of lifestyle on cytochrome P450 monooxygenase repertoire is clearly evident in the bacterial phylum Firmicutes.Scientific reports · 2020Article
- Comparative Analysis, Structural Insights, and Substrate/Drug Interaction of CYP128A1 inInternational journal of molecular sciences · 2020Article
- More P450s Are Involved in Secondary Metabolite Biosynthesis inInternational journal of molecular sciences · 2020Article
- Comprehensive Analyses of Cytochrome P450 Monooxygenases and Secondary Metabolite Biosynthetic Gene Clusters inInternational journal of molecular sciences · 2020Article
- Microbiome is a functional modifier of P450 drug metabolism.Current pharmacology reports · 2019Article
- Distribution and Diversity of Cytochrome P450 Monooxygenases in the Fungal ClassInternational journal of molecular sciences · 2019Article
- Cytochrome P450 Monooxygenase CYP139 Family Involved in the Synthesis of Secondary Metabolites in 824 Mycobacterial Species.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome P450 monooxygenases (P450s) found in all domains of life are known for their catalytic versatility and stereo- and regio-specific activity. While the impact of lifestyle on P450 evolution was reported in many eukaryotes, this remains to be addressed in bacteria. In this report, Streptomyces and Mycobacterium, belonging to the phylum Actinobacteria, were studied owing to their contrasting lifestyles and impacts on human. Analyses of all P450s and those predicted to be associated with secondary metabolism have revealed that different lifestyles have affected the evolution of P450s in these bacterial genera. We have found that while species in both genera have essentially the same number of P450s in the genome, Streptomyces P450s are much more diverse than those of Mycobacterium. Moreover, despite both belonging to Actinobacteria, only 21 P450 families were common, and 123 and 56 families were found to be unique to Streptomyces and Mycobacterium, respectively. The presence of a large and diverse number of P450s in Streptomyces secondary metabolism contributes to antibiotic diversity, helping to secure the niche. Conversely, based on the currently available functional data, types of secondary metabolic pathways and associated P450s, mycobacterial P450s seem to play a role in utilization or synthesis of lipids.
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