ArticleScientific reports2019
Physicochemical, cytotoxicity and in vivo biocompatibility of a high-plasticity calcium-silicate based material.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Effect of Powder-to-Liquid Ratio on pH, Calcium Ion Release, and Solubility Behaviors of Endodontic Bioceramics: An In Vitro Study.Journal of functional biomaterials · 2026Article
- Chemical Stability and Bond Strength of Endodontic Sealers Exposed to Acidic, Alkaline and Protein-Rich Environments: An In Vitro Investigation.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Evaluation of marginal adaptation and bond strength of apical root canal plugs using different bioceramic cements.BMC oral health · 2026Article
- 3D Bioprinted Natural Hydrogels: Rheological Characterization, Cytotoxicity, and Printability Assessment of a Polysaccharide-Based Bioink.ACS omega · 2026Article
- Effect of moisture and pH on setting time and microhardness of three premixed calcium silicate-based root canal sealers: an in vitro experimental study.Restorative dentistry & endodontics · 2025Article
- Trifunctional Sialylation-Based SF-ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone-Vessel Regeneration in Osteoporotic Bone Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- An Evaluation of the Cytocompatibility of Endodontic Bioceramics in Human Periodontal-Ligament-Derived Cells.Journal of functional biomaterials · 2024Article
- Volumetric change of calcium silicate-based repair materials in a simulated inflammatory environment: A micro-computed tomography study.Journal of conservative dentistry and endodontics · 2024Article
- Assessing the impact of dental restorative materials on fibroblast cells: an immunohistochemical and ELISA analysis.Scientific reports · 2024Article
- Evaluation of the genotoxicity, cytotoxicity, and bioactivity of calcium silicate-based cements.BMC oral health · 2024Article
- Cytotoxicity, Differentiation, and Biocompatibility of Root-End Filling: A Comprehensive Study.Biomimetics (Basel, Switzerland) · 2023Article
- High-plasticity mineral trioxide aggregate and its effects on M1 and M2 macrophage viability and adherence, phagocyte activity, production of reactive oxygen species, and cytokines.Restorative dentistry & endodontics · 2023Article
- Dental and composite resin discoloration induced by different hydraulic calcium silicate-based cements: two-year in vitro assessment.Journal of applied oral science : revista FOB · 2023Article
- Biological and chemical properties of five mineral oxides and of mineral trioxide aggregate repair high plasticity: an in vitro study.Scientific reports · 2022Article
- Biocompatibility of a New Calcium Silicate-Based Root Canal Sealer Mediated via the Modulation of Macrophage Polarization in a Rat Model.Materials (Basel, Switzerland) · 2022Article
- MTA-Based Cements: Biocompatibility and Effects on the Gene Expression of Collagen Type 1 and TGF-BioMed research international · 2022Article
- New Bioactive Calcium Silicate Cement Mineral Trioxide Aggregate Repair High Plasticity (MTA HP)-A Systematic Review.Materials (Basel, Switzerland) · 2021Review
- A micro-computed tomographic study using a novel test model to assess the filling ability and volumetric changes of bioceramic root repair materials.Restorative dentistry & endodontics · 2021Article
- Subcutaneous Implantation Assessment of New Calcium-Silicate Based Sealer for Warm Obturation.Biomedicines · 2021Article
- The Influence of New Silicate Cement Mineral Trioxide Aggregate (MTA Repair HP) on Metalloproteinase MMP-2 and MMP-9 Expression in Cultured THP-1 Macrophages.International journal of molecular sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this work was to evaluate the physicochemical properties, the cytotoxicity and in vivo biocompatibility of MTA Repair HP (MTA HP) and White MTA (WMTA). The setting time, flow, radiopacity and water solubility were assessed. To the cytotoxicity assay, primary human osteoblast cells were exposed to several dilutions of both materials eluates. MTT assay, apoptosis assay and cell adhesion assay were performed. The in vivo biocompatibility was evaluated through histological analysis using different staining techniques. No differences were observed between MTA HP and WMTA for setting time, radiopacity, solubility and water absorption (P > 0.05). However, MTA HP showed a significantly higher flow when compared to WMTA (P < 0.05). Cell viability results revealed that the extracts of WMTA and MTA HP promoted the viability of osteoblasts. After incubation of cells with the endodontic cement extracts, the percentage of apoptotic or necrotic cells was very low (<3%). Furthermore, SEM results showed a high degree of cell proliferation and adhesion on both groups. MTA HP showed similar in vivo biocompatibility to the WMTA and the control group in all time-points. The MTA HP presented adequate physicochemical and biological properties with improved flow ability when compared to WMTA. Such improved flow ability may be a result of the addition of a plasticizing agent and should be related to an improvement in the handling of MTA HP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.