Evidence map›Paper›PMID 30850645›Full record

ArticleScientific reports2019

Degradation kinetics of cold plasma-treated antibiotics and their antimicrobial activity.

Chaitanya Sarangapani, Dana Ziuzina, Patrice Behan, Daniela Boehm, Brendan F Gilmore, P J Cullen, Paula Bourke

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 103 citations in OpenAlex.

  1. Review
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  8. Deciphering the biocontrol strategies ofCurrent research in microbial sciences · 2025
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  12. Cold plasma for enhanced water purification.Sustainable microbiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Chaitanya SarangapaniSchool of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland.
Dana ZiuzinaSchool of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland. dana.ziuzina@dit.ie.ORCID 0000-0003-2142-9095
Patrice BehanSchool of Chemical and Pharmaceutical Sciences, Technological University Dublin, Dublin, Ireland.
Daniela BoehmSchool of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland.
Brendan F GilmoreSchool of Pharmacy, Queens University Belfast, Belfast, BT9 7BL, United Kingdom.
P J CullenSchool of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland.
Paula BourkeSchool of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland.
Technological University Dublin · IEQueen's University Belfast · GBThe University of Sydney · AU

Funding

Biotechnology and Biological Sciences Research Council BB/P008496/1
6 · The paper itself

Abstract

Antibiotics, such as ofloxacin (OFX) and ciprofloxacin (CFX), are often detected in considerable concentrations in both wastewater effluents and surface water. This poses a risk to non-target organisms and to human health. The aim of this work was to study atmospheric cold plasma (ACP) degradation of antibiotics in water and meat effluent and to explore any residual antimicrobial activity of samples submitted to the plasma process. The results revealed that ACP successfully degraded the studied antibiotics and that the reaction mechanism is principally related to attack by hydroxyl radicals and ozone. According to the disk diffusion assay, the activity of both antibiotics was considerably reduced by the plasma treatment. However, a microdilution method demonstrated that CFX exhibited higher antimicrobial activity after ACP treatment than the corresponding control revealing a potentially new platform for future research to improve the efficiency of conventional antibiotic treatments. Importantly, short-term exposures to sub-lethal concentrations of the antibiotic equally reduced bacterial susceptibility to both ACP treated and untreated CFX. As a remediation process, ACP removal of antibiotics in complex wastewater effluents is possible. However, it is recommended that plasma encompass degradant structure activity relationships to ensure that biological activity is eliminated against non-target organisms and that life cycle safety of antibiotic compounds is achieved.

Indexed as

Plasma GasesAnti-Bacterial AgentsCiprofloxacinDisk Diffusion Antimicrobial TestsEscherichia coliFree Radical ScavengersKineticsNitratesOfloxacinOxalic AcidPseudomonas aeruginosaWastewaterWater PurificationAnti-Bacterial AgentsCiprofloxacinFree Radical ScavengersNitratesOfloxacinOxalic AcidPlasma GasesWastewater

Identifiers

PMID30850645
PMCPMC6408491
OpenAlexW2920610809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.