Evidence map›Paper›PMID 30850611›Full record

ArticleNature communications2019

Systematic comparison of respiratory syncytial virus-induced memory B cell responses in two anatomical compartments.

Laila Shehata, Wendy F Wieland-Alter, Daniel P Maurer, Eunice Chen, Ruth I Connor, Peter F Wright, Laura M Walker

Open access · goldAbstract readComparative Study
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Lung-resident lymphocytes and their roles in respiratory infections and chronic respiratory diseases.Chinese medical journal pulmonary and critical care medicine · 2024
    Review
  7. Immune Response to Respiratory Viral Infections.International journal of molecular sciences · 2024
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Strategies for active and passive pediatric RSV immunization.Therapeutic advances in vaccines and immunotherapy · 2021
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Laila ShehataAdimab LLC, Lebanon, NH, 03766, USA.
Wendy F Wieland-AlterDepartment of Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.
Daniel P MaurerAdimab LLC, Lebanon, NH, 03766, USA.
Eunice ChenDepartment of Surgery, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.ORCID http://orcid.org/0000-0003-2386-9297
Ruth I ConnorDepartment of Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.
Peter F WrightDepartment of Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.
Laura M WalkerAdimab LLC, Lebanon, NH, 03766, USA. laura.walker@adimab.com.
Dartmouth College · USAdimab (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a leading cause of hospitalization in infants and young children. Although it is widely agreed that an RSV vaccine should induce both mucosal and systemic antibody responses, little is known about the B cell response to RSV in mucosa-associated lymphoid tissues. Here, we analyze this response by isolating 806 RSV F-specific antibodies from paired adenoid and peripheral blood samples from 4 young children. Overall, the adenoid-derived antibodies show higher binding affinities and neutralization potencies compared to antibodies isolated from peripheral blood. Approximately 25% of the neutralizing antibodies isolated from adenoids originate from a unique population of IgM

Indexed as

Immunity, MucosalAdenoidsAntibodies, NeutralizingAntibodies, ViralAntibody AffinityAntibody SpecificityBiomarkersB-LymphocytesChild, PreschoolCloning, MolecularFemaleGene ExpressionGenetic VectorsHumansImmunoglobulin DImmunoglobulin MAntibodies, NeutralizingAntibodies, ViralBiomarkersImmunoglobulin DImmunoglobulin MRecombinant Proteins

Identifiers

PMID30850611
PMCPMC6408481
OpenAlexW2920674479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.