Evidence map›Paper›PMID 30850610›Full record

ArticleNature communications2019

Characterization of the hemodynamic response function in white matter tracts for event-related fMRI.

Muwei Li, Allen T Newton, Adam W Anderson, Zhaohua Ding, John C Gore

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Electrophysiological features of signals recorded from white matter.bioRxiv : the preprint server for biology · 2026
    Article
  5. White-Matter BOLD Encoding Beyond Marginal Connectivity.bioRxiv : the preprint server for biology · 2026
    Article
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Muwei LiVanderbilt University Institute of Imaging Science, 1161 21st Ave. S, Medical Center North, AA-1105, Nashville, TN, 37232, USA.ORCID http://orcid.org/0000-0003-3596-9287
Allen T NewtonVanderbilt University Institute of Imaging Science, 1161 21st Ave. S, Medical Center North, AA-1105, Nashville, TN, 37232, USA.
Adam W AndersonVanderbilt University Institute of Imaging Science, 1161 21st Ave. S, Medical Center North, AA-1105, Nashville, TN, 37232, USA.
Zhaohua DingVanderbilt University Institute of Imaging Science, 1161 21st Ave. S, Medical Center North, AA-1105, Nashville, TN, 37232, USA. zhaohua.ding@vanderbilt.edu.
John C GoreVanderbilt University Institute of Imaging Science, 1161 21st Ave. S, Medical Center North, AA-1105, Nashville, TN, 37232, USA. john.gore@vumc.org.
Vanderbilt University · US

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Resting State Connectivity in White MatterR01NS093669 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2016 to 2020
$2.7M
Replacement and Upgrade of a 3T MR Scanner for ResearchS10OD021771 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2016 to 2016
$2.0M
NICHD NIH HHS U54 HD083211NIH HHS R01 NS093669NIH HHS S10 OD021771NINDS NIH HHS R01 NS093669
6 · The paper itself

Abstract

Accurate estimates of the BOLD hemodynamic response function (HRF) are crucial for the interpretation and analysis of event-related functional MRI data. To date, however, there have been no comprehensive measurements of the HRF in white matter (WM) despite increasing evidence that BOLD signals in WM change after a stimulus. We performed an event-related cognitive task (Stroop color-word interference) to measure the HRF in selected human WM pathways. The task was chosen in order to produce robust, distributed centers of activity throughout the cortex. To measure the HRF in WM, fiber tracts were reconstructed between each pair of activated cortical areas. We observed clear task-specific HRFs with reduced magnitudes, delayed onsets and prolonged initial dips in WM tracts compared with activated grey matter, thus calling for significant changes to current standard models for accurately characterizing the HRFs in WM and for modifications of standard methods of analysis of functional imaging data.

Indexed as

AdultCerebral CortexCerebrovascular CirculationFemaleGray MatterHealthy VolunteersHemodynamicsHemoglobinsHumansMagnetic Resonance ImagingMaleNerve NetOxygenPattern Recognition, VisualStroop TestWhite MatterHemoglobinsOxygen

Identifiers

PMID30850610
PMCPMC6408456
OpenAlexW2922379309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.