Evidence map›Paper›PMID 30850598›Full record

ArticleNature communications2019

Inter-annual variation in seasonal dengue epidemics driven by multiple interacting factors in Guangzhou, China.

Rachel J Oidtman, Shengjie Lai, Zhoujie Huang, Juan Yang, Amir S Siraj, Robert C Reiner, Andrew J Tatem, T Alex Perkins, Hongjie Yu

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

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  9. Climate, demography, immunology, and virology combine to drive two decades of dengue virus dynamics in Cambodia.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 5 countries.

Rachel J OidtmanDepartment of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, 46556, IN, USA.
Shengjie LaiSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, 200032, China.ORCID http://orcid.org/0000-0001-9781-8148
Zhoujie HuangSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, 200032, China.
Juan YangSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, 200032, China.
Amir S SirajDepartment of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, 46556, IN, USA.ORCID http://orcid.org/0000-0002-9275-0380
Robert C ReinerInstitute for Health and Metrics and Evaluation, University of Washington, Seattle, 98195, WA, USA.
Andrew J TatemWorldPop, Department of Geography and Environment, University of Southampton, Southampton, SO17 1BJ, UK.
T Alex PerkinsDepartment of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, 46556, IN, USA. taperkins@nd.edu.
Hongjie YuSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, 200032, China. yhj@fudan.edu.cn.
Fudan University · CNUniversity of Notre Dame · USFlowminder Foundation · SEUniversity of Washington · US

Funding

Virology &ImmunologyU19AI051915 · NIAID · NATIONAL CENTER FOR AIDS/STD CONTROL AND PREVENTION · PI SHAO, YIMING · 2002 to 2009
$21.6M
NIAID NIH HHS U19 AI051915Wellcome Trust
6 · The paper itself

Abstract

Vector-borne diseases display wide inter-annual variation in seasonal epidemic size due to their complex dependence on temporally variable environmental conditions and other factors. In 2014, Guangzhou, China experienced its worst dengue epidemic on record, with incidence exceeding the historical average by two orders of magnitude. To disentangle contributions from multiple factors to inter-annual variation in epidemic size, we fitted a semi-mechanistic model to time series data from 2005-2015 and performed a series of factorial simulation experiments in which seasonal epidemics were simulated under all combinations of year-specific patterns of four time-varying factors: imported cases, mosquito density, temperature, and residual variation in local conditions not explicitly represented in the model. Our results indicate that while epidemics in most years were limited by unfavorable conditions with respect to one or more factors, the epidemic in 2014 was made possible by the combination of favorable conditions for all factors considered in our analysis.

Indexed as

EpidemicsModels, StatisticalAnimalsChinaComputer SimulationDengueDengue VirusHumansIncidenceMosquito VectorsMultivariate AnalysisPopulation DensitySeasonsTemperatureTravel

Identifiers

PMID30850598
PMCPMC6408462
OpenAlexW2953342850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.