Evidence map›Paper›PMID 30850550›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Divergent kinase regulates membrane ultrastructure of the

Tsebaot Beraki, Xiaoyu Hu, Malgorzata Broncel, Joanna C Young, William J O'Shaughnessy, Dominika Borek, Moritz Treeck, Michael L Reese

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
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  5. Review
  6. TwomBio · 2024
    Article
  7. GRA47 and GRA72 arebioRxiv : the preprint server for biology · 2023
    Article
  8. Article
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  15. Released Parasite-Derived Kinases as Novel Targets for Antiparasitic Therapies.Frontiers in cellular and infection microbiology · 2022
    Review
  16. Review
  17. Article
  18. Protein kinases in Toxoplasma gondii.International journal for parasitology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Tsebaot BerakiDepartment of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, TX 75390.
Xiaoyu HuDepartment of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, TX 75390.
Malgorzata BroncelSignalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, NW1 1AT London United Kingdom.
Joanna C YoungSignalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, NW1 1AT London United Kingdom.
William J O'ShaughnessyDepartment of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, TX 75390.
Dominika BorekDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-4321-6253
Moritz TreeckSignalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, NW1 1AT London United Kingdom.ORCID 0000-0002-9727-6657
Michael L ReeseDepartment of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, TX 75390; Michael.Reese@UTSouthwestern.edu.ORCID 0000-0001-9401-9594
The University of Texas Southwestern Medical Center · USThe Francis Crick Institute · GB

Funding

DIVISION OF CELL &MOLECULAR BIOLOGY TRAINING PROGRAMT32GM008203 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI COBB, MELANIE H. · 1987 to 2018
$7.0M
Dissecting the calcium dependent phosphorylation network of Toxoplasma gondiiR01AI123457 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI ARRIZABALAGA, GUSTAVO A, TREECK, MORITZ · 2016 to 2020
$2.7M
X-ray data analysis in the presence of structural variability - Administrative SupplementR01GM117080 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MINOR, WLADEK, OTWINOWSKI, ZBYSZEK · 2015 to 2018
$1.4M
Radioprotectants for structural biologyR21GM126406 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI BOREK, DOMINIKA MARTA · 2018 to 2019
$446k
Cancer Research UK FC001189NIAID NIH HHS R01 AI123457NIGMS NIH HHS R01 GM117080NIGMS NIH HHS R21 GM126406NIGMS NIH HHS T32 GM008203Wellcome Trust FC001189
6 · The paper itself

Abstract

Apicomplexan parasites replicate within a protective organelle, called the parasitophorous vacuole (PV). The

Indexed as

Crystallography, X-RayGene Knockout TechniquesHost-Parasite InteractionsMembranesModels, MolecularPhosphorylationProtein ConformationProtein KinasesProtein TransportProtozoan ProteinsSignal TransductionToxoplasmaVacuolesVirulenceProtein KinasesProtozoan Proteinschaperonehost–pathogen interactionkinasephosphorylationpseudokinase

Identifiers

PMID30850550
PMCPMC6442604
OpenAlexW2921753065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.