ArticleProceedings of the National Academy of Sciences of the United States of America2019
Energy conservation by a hydrogenase-dependent chemiosmotic mechanism in an ancient metabolic pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 99 citations in OpenAlex.
- Intermediate stages in the origin of metabolism at a phosphorylating hydrothermal vent.Science advances · 2026Article
- Methanol Metabolism in the Cytochrome and Menaquinone-Containing Acetogen Moorella thermoacetica.Environmental microbiology · 2026Article
- Carbon monoxide metabolism in freshwater anaerobic methanotrophic archaea.Nature communications · 2026Article
- Comparative Physiology and Genomics of Thermincola and Carboxydocella Strains and Description of Two Novel Isolates.Environmental microbiology · 2026Article
- Carbon monoxide-driven proton respiration enables facultative anaerobes to survive electron acceptor limitation.The ISME journal · 2026Article
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- Effects of Nitrate on Hydrogenogenic Carbon Monoxide Oxidation in Parageobacillus thermoglucosidasius.Environmental microbiology reports · 2025Article
- Conversion of pyridoxal to pyridoxamine with NHThe FEBS journal · 2025Article
- A megatransposon drives the adaptation of Thermoanaerobacter kivui to carbon monoxide.Nature communications · 2025Article
- Methanol and Carbon Monoxide Metabolism of the Thermophile Moorella caeni.Environmental microbiology · 2025Article
- Isolation and characterization ofInternational journal of systematic and evolutionary microbiology · 2025Article
- The early evolution of the glycolytic pathway from autotrophic origins to glycogen and back.FEMS microbiology reviews · 2025Review
- Phylogenetic diversity of putative nickel-containing carbon monoxide dehydrogenase-encoding prokaryotes in the human gut microbiome.Microbial genomics · 2024Article
- Asgard archaea modulate potential methanogenesis substrates in wetland soil.Nature communications · 2024Article
- The effects of synthesis gas feedstocks and oxygen perturbation on hydrogen production by Parageobacillus thermoglucosidasius.Microbial cell factories · 2024Article
- Extremophiles in a changing world.Extremophiles : life under extreme conditions · 2024Review
- The energy-converting hydrogenase Ech2 is important for the growth of the thermophilic acetogenMicrobiology spectrum · 2024Article
- Ferredoxin reduction by hydrogen with iron functions as an evolutionary precursor of flavin-based electron bifurcation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Nickel-organo compounds as potential enzyme precursors under simulated early Earth conditions.Communications chemistry · 2024Article
- Engineered acetogenic bacteria as microbial cell factory for diversified biochemicals.Frontiers in bioengineering and biotechnology · 2024Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ancient reductive acetyl-CoA pathway is employed by acetogenic bacteria to form acetate from inorganic energy sources. Since the central pathway does not gain net ATP by substrate-level phosphorylation, chemolithoautotrophic growth relies on the additional formation of ATP via a chemiosmotic mechanism. Genome analyses indicated that some acetogens only have an energy-converting, ion-translocating hydrogenase (Ech) as a potential respiratory enzyme. Although the Ech-encoding genes are widely distributed in nature, the proposed function of Ech as an ion-translocating chemiosmotic coupling site has neither been demonstrated in bacteria nor has it been demonstrated that it can be the only energetic coupling sites in microorganisms that depend on a chemiosmotic mechanism for energy conservation. Here, we show that the Ech complex of the thermophilic acetogenic bacterium
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