Evidence map›Paper›PMID 30850542›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Interplay between DNA sequence and negative superhelicity drives R-loop structures.

Robert Stolz, Shaheen Sulthana, Stella R Hartono, Maika Malig, Craig J Benham, Frederic Chedin

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 133 citations in OpenAlex.

  1. Article
  2. Article
  3. Topology Resetting During Transcription-Coupled Nucleotide Excision Repair.International journal of molecular sciences · 2026
    Review
  4. Sequence and structural alignments reveal insights into ANKLE2 evolution and function.Protein science : a publication of the Protein Society · 2026
    Article
  5. Article
  6. DNA topological regulation in RNA polymerase II transcription.Cellular & molecular biology letters · 2026
    Review
  7. Prime editing in mammals: From promise to practicalities.Molecular therapy. Nucleic acids · 2025
    Review
  8. Article
  9. Protein-mediated stabilization and nicking of the nontemplate DNA strand dramatically affect R-loop formation in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. NAT10 andScience advances · 2025
    Article
  19. Article
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Robert StolzDepartment of Molecular and Cellular Biology, University of California, Davis, CA 95616.
Shaheen SulthanaDepartment of Molecular and Cellular Biology, University of California, Davis, CA 95616.
Stella R HartonoDepartment of Molecular and Cellular Biology, University of California, Davis, CA 95616.
Maika MaligDepartment of Molecular and Cellular Biology, University of California, Davis, CA 95616.
Craig J BenhamDepartment of Mathematics, University of California, Davis, CA 95616; cjbenham@ucdavis.edu flchedin@ucdavis.edu.
Frederic ChedinDepartment of Molecular and Cellular Biology, University of California, Davis, CA 95616; cjbenham@ucdavis.edu flchedin@ucdavis.edu.ORCID 0000-0002-1306-5335
University of California, Davis · US

Funding

Training Program in Biomolecular TechnologyT32GM008799 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEACH, J. KENT · 2002 to 2016
$2.4M
Genomic profiling of pathological R-loop formation in human diseases.R01GM120607 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEDIN, FREDERIC LOUIS · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM120607NIGMS NIH HHS T32 GM008799
6 · The paper itself

Abstract

R-loops are abundant three-stranded nucleic-acid structures that form

Indexed as

Base SequenceNucleic Acid ConformationDNADNA, Single-StrandedDNA, SuperhelicalModels, GeneticNucleic Acid HybridizationPlasmidsRNATranscription, GeneticDNADNA, Single-StrandedDNA, SuperhelicalRNADNA topologymodelingR-looptranscription

Identifiers

PMID30850542
PMCPMC6442632
OpenAlexW2921848211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.