Evidence map›Paper›PMID 30850541›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Point centromere activity requires an optimal level of centromeric noncoding RNA.

Yick Hin Ling, Karen Wing Yee Yuen

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. An interdependent Cbf1-CCAN interaction stabilizes the budding yeast kinetochore.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
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  5. Article
  6. Review
  7. Article
  8. Review
  9. Preserving centromere identity: right amounts of CENP-A at the right place and time.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  10. Article
  11. Fungi as models of centromere innovation: from DNA sequence to 3-dimensional arrangement.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  12. Identification of chromatin-associated RNAs at human centromeres.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yick Hin LingSchool of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
Karen Wing Yee YuenSchool of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong kwyyuen@hku.hk.ORCID 0000-0002-2139-5465
University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In budding yeast, which possesses simple point centromeres, we discovered that all of its centromeres express long noncoding RNAs (cenRNAs), especially in S phase. Induction of cenRNAs coincides with CENP-A

Indexed as

Aurora KinasesBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCarrier ProteinsCentromereChromatinChromosomal Proteins, Non-HistoneChromosome SegregationChromosomes, FungalDNA-Binding ProteinsDNA ReplicationGene DeletionHistonesMicrotubule-Associated ProteinsRNA InterferenceRNA, UntranslatedSaccharomyces cerevisiaeAurora KinasesBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBir1 protein, S cerevisiaeCarrier ProteinsCBF1 protein, S cerevisiaecentromere protein CChromatinChromosomal Proteins, Non-HistoneCSE4 protein, S cerevisiaeDNA-Binding ProteinsHistonesHtz1 protein, S cerevisiaeIPL1 protein, S cerevisiaeMicrotubule-Associated ProteinsMIF2 protein, S cerevisiaeRNA, UntranslatedSaccharomyces cerevisiae ProteinsScm3 protein, S cerevisiaeSli15 protein, S cerevisiaecentromere-binding factor Cbf1centromeric transcriptionchromosome instabilityhistone H2A variant Htz1long noncoding RNA

Identifiers

PMID30850541
PMCPMC6442628
OpenAlexW2922301063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.