Evidence map›Paper›PMID 30850535›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Mitochondrial UPR repression during

Pan Deng, Nandhitha Uma Naresh, Yunguang Du, Lilian T Lamech, Jun Yu, Lihua Julie Zhu, Read Pukkila-Worley, Cole M Haynes

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Unzipping the defense: a comprehensive review on bZIP transcription factors inFrontiers in cellular and infection microbiology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Modeling Host-Pathogen Interactions inInternational journal of molecular sciences · 2024
    Review
  13. Mitochondrial recovery by the UPRSeminars in cell & developmental biology · 2024
    Review
  14. Dual roles of UPRJournal of molecular medicine (Berlin, Germany) · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Mitochondrial Dysfunction in Bacterial Infections.Pathogens (Basel, Switzerland) · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Pan DengDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Nandhitha Uma NareshDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Yunguang DuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Lilian T LamechCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Jun YuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Lihua Julie ZhuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Read Pukkila-WorleyDivision of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605.
Cole M HaynesDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605; cole.haynes@umassmed.edu.
University of Massachusetts Chan Medical School · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
An Immune Surveillance Network in C. elegansR01AI130289 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PUKKILA-WORLEY, READ · 2017 to 2025
$4.6M
MAINTENANCE OF MITOCHONDRIAL PROTEIN FOLDING AS AN AGING EFFECTORR01AG040061 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HAYNES, COLE M · 2011 to 2020
$3.6M
Coordinated Repair and Regeneration of Defective MitochondriaR37AG047182 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Cole M Haynes · 2020 to 2026
$3.2M
Coordinated Repair and Regeneration of Defective MitochondriaR01AG047182 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HAYNES, COLE M · 2015 to 2019
$2.1M
NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI130289NIA NIH HHS R01 AG040061NIA NIH HHS R01 AG047182NIA NIH HHS R37 AG047182NIH HHS P40 OD010440
6 · The paper itself

Abstract

Mitochondria generate most cellular energy and are targeted by multiple pathogens during infection. In turn, metazoans employ surveillance mechanisms such as the mitochondrial unfolded protein response (UPR

Indexed as

Unfolded Protein ResponseAnimalsBasic-Leucine Zipper Transcription FactorsCaenorhabditis elegansCaenorhabditis elegans ProteinsMitochondriaPseudomonas aeruginosaPseudomonas InfectionsTranscription FactorsUbiquitin-Protein LigasesBasic-Leucine Zipper Transcription FactorsCaenorhabditis elegans ProteinsTranscription FactorsUbiquitin-Protein Ligaseswwp-1 protein, C eleganszip-3 protein, C elegansATFS-1immunitymitochondrial UPRUPRmtZIP-3

Identifiers

PMID30850535
PMCPMC6442607
OpenAlexW2921538673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.