ArticleProceedings of the National Academy of Sciences of the United States of America2019
Mechanisms for achieving high speed and efficiency in biomolecular machines.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
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- Molecular Machines and Microrobots: Nanoarchitectonics Developments and On-Water Performances.Micromachines · 2022Review
- Controlling dynamics in extended molecular frameworks.Nature reviews. Chemistry · 2022Review
- Tuning the Force, Speed, and Efficiency of an Autonomous Chemically Fueled Information Ratchet.Journal of the American Chemical Society · 2022Article
- Insights from an information thermodynamics analysis of a synthetic molecular motor.Nature chemistry · 2022Article
- Thermodynamic selection: mechanisms and scenarios.New journal of physics · 2022Article
- Imipramine induces hyperactivity in rats pretreated with ouabain: Implications to the mania switch induced by antidepressants.Journal of affective disorders · 2022Article
- FFrontiers in microbiology · 2022Review
- Evolution of mechanical cooperativity among myosin II motors.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Reversible catalysis.Nature reviews. Chemistry · 2021Review
- How Do Cells Adapt? Stories Told in Landscapes.Annual review of chemical and biomolecular engineering · 2020Review
- A thermodynamic function of glycogen in brain and muscle.Progress in neurobiology · 2020Article
- Opposing Pressures of Speed and Efficiency Guide the Evolution of Molecular Machines.Molecular biology and evolution · 2019Article
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2 authors.
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Abstract
How does a biomolecular machine achieve high speed at high efficiency? We explore optimization principles using a simple two-state dynamical model. With this model, we establish physical principles-such as the optimal way to distribute free-energy changes and barriers across the machine cycle-and connect them to biological mechanisms. We find that a machine can achieve high speed without sacrificing efficiency by varying its conformational free energy to directly link the downhill, chemical energy to the uphill, mechanical work and by splitting a large work step into more numerous, smaller substeps. Experimental evidence suggests that these mechanisms are commonly used by biomolecular machines. This model is useful for exploring questions of evolution and optimization in molecular machines.
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