ArticleProceedings of the National Academy of Sciences of the United States of America2019
Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
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37 citing papers in PubMed, 79 citations in OpenAlex.
- mGluR5 in ECAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CCK2R regulates METH-induced CPP acquisition within VTA-BLA-BNST circuit in male mice.Translational psychiatry · 2026Article
- Cholecystokinin upregulation in mPFC leads to social defeat-induced anxiety susceptibility in neuroligin 3 R451C knockin mice.Molecular autism · 2026Article
- Entorhinal Cholecystokinin in Alzheimer's Disease: Its Earliest Vulnerability and Rescue Effects Across Different Disease Stages in a Mouse Model.Cellular and molecular neurobiology · 2026Article
- Role of Neuronal Cholecystokinin Receptor: An Emerging Therapeutic Target for Ameliorating Neurological Diseases.Molecular neurobiology · 2025Review
- Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation.Nature communications · 2025Article
- Article
- Cholecystokinin ameliorates cognitive impairment via inhibiting microglia phagocytosis of excitatory synapses in sepsis-associated encephalopathy mice.Journal of neuroinflammation · 2025Article
- Cholecystokinin-expressing GABA neurons elicit long-term potentiation in the cortical inhibitory synapses and attenuate sound-shock associative memory.Scientific reports · 2025Article
- Article
- Cholecystokinin facilitates the formation of long-term heterosynaptic plasticity in the distal subiculum.Communications biology · 2025Article
- Article
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Roles of KCNA2 in Neurological Diseases: from Physiology to Pathology.Molecular neurobiology · 2024Review
- Basolateral amygdala parvalbumin and cholecystokinin-expressing GABAergic neurons modulate depressive and anxiety-like behaviors.Translational psychiatry · 2024Article
- Cholecystokinin B receptor agonists alleviates anterograde amnesia in cholecystokinin-deficient and aged Alzheimer's disease mice.Alzheimer's research & therapy · 2024Article
- Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex.eLife · 2024Article
- Distribution of cionin, a cholecystokinin/gastrin family peptide, and its receptor in the central nervous system of Ciona intestinalis type A.Scientific reports · 2024Article
- Article
- Potentiated GABAergic neuronal activities in the basolateral amygdala alleviate stress-induced depressive behaviors.CNS neuroscience & therapeutics · 2024Article
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Authors and funding
36 authors at 5 institutions in 2 countries.
Xi ChenDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Xiao LiDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Yin Ting WongDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Xuejiao ZhengDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Haitao WangKey Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 510530 Guangzhou, China.
Yujie PengDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Hemin FengDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Jingyu FengDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Joewel T BaibadoDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Robert JeskyDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Zhedi WangDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Hui XieDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Wenjian SunDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Zicong ZhangDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.ORCID 0000-0002-6453-5528
Xu ZhangDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Ling HeDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Nan ZhangDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Zhijian ZhangCenter for Brain Science, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, 430071 Wuhan, China.
Peng TangDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Junfeng SuDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Ling-Li HuKey Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 510530 Guangzhou, China.
Qing LiuCenter for Brain Science, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, 430071 Wuhan, China.
Xiaobin HeCenter for Brain Science, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, 430071 Wuhan, China.
Ailian TanDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Xia SunSchool of Medicine, Hangzhou Normal University, 310018 Hangzhou, China.
Min LiDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Kelvin WongDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Xiaoyu WangDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Hon-Yeung CheungDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong.
Daisy Kwok-Yan ShumSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Ken K L YungDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
Ying-Shing ChanSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Micky TortorellaKey Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 510530 Guangzhou, China.
Yiping GuoKey Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 510530 Guangzhou, China.
Fuqiang XuCenter for Brain Science, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, 430071 Wuhan, China.
Jufang HeDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong; jufanghe@cityu.edu.hk.
City University of Hong Kong · HKChinese Academy of Sciences · CNUniversity of Hong Kong · HKHangzhou Normal University · CNHong Kong Baptist University · HK
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces LTP. CCK
Indexed as
AnimalsAuditory CortexBehavior, AnimalCholecystokininElectric StimulationEntorhinal CortexFemaleHippocampusLong-Term PotentiationMaleMemoryMiceMice, Inbred C57BLMice, KnockoutNeocortexNeuronsCholecystokininN-MethylaspartateReceptor, Cholecystokinin BReceptors, N-Methyl-D-Aspartatecholecystokininentorhinal cortexlong-term potentiationmemoryNMDA receptor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.