Evidence map›Paper›PMID 30850502›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Side Effects of CXC-Chemokine Receptor 4-Directed Endoradiotherapy with Pentixather Before Hematopoietic Stem Cell Transplantation.

Sabine Maurer, Peter Herhaus, Romina Lippenmeyer, Heribert Hänscheid, Malte Kircher, Andreas Schirbel, H Carlo Maurer, Andreas K Buck, Hans-Jürgen Wester, Hermann Einsele and 3 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Review
  2. Article
  3. Is CXCR4 Theranostics in Oncologic, Cardiovascular, and Inflammatory Diseases Really Happening?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. ComparingCancers · 2025
    Article
  12. Review
  13. Article
  14. Chemokine Receptor 4-Targeted PET/CT with [Molecular imaging and biology · 2024
    Article
  15. Article
  16. Advances in Radioligand Theranostics in Oncology.Molecular diagnosis & therapy · 2024
    Review
  17. Review
  18. CXCR4-directed PET/CT with [European journal of nuclear medicine and molecular imaging · 2024
    Article
  19. Theranostics in Hematooncology.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sabine MaurerIII. Medical Department, Hematology and Medical Oncology, Technische Universität München, Munich, Germany.
Peter HerhausIII. Medical Department, Hematology and Medical Oncology, Technische Universität München, Munich, Germany.
Romina LippenmeyerDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Heribert HänscheidDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Malte KircherDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Andreas SchirbelDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
H Carlo MaurerII. Medical Department, Gastroenterology and Hepatology, Technische Universtät München, Munich, Germany.
Andreas K BuckDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Hans-Jürgen WesterPharmaceutical Radiochemistry, Technische Universität München, Munich, Germany.
Hermann EinseleHematology and Medical Oncology, Medical Department II, University Hospital Würzburg, Würzburg, Germany; and.
Götz-Ulrich GrigoleitHematology and Medical Oncology, Medical Department II, University Hospital Würzburg, Würzburg, Germany; and.
Ulrich KellerIII. Medical Department, Hematology and Medical Oncology, Technische Universität München, Munich, Germany ulrich.keller@charite.de.
Constantin LapaDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chemokine receptor CXC-chemokine receptor 4 (CXCR4) is a transmembrane receptor involved in survival, proliferation, and dissemination of different cancers, including hematopoietic malignancies. Relapsed or refractory hematopoietic cancers are frequently resistant to conventional therapy, and novel highly active strategies are urgently needed. CXCR4-directed endoradiotherapy constitutes a highly promising targeted therapeutic concept. Here, we investigated the adverse effects of this novel treatment approach.

Indexed as

Hematopoietic Stem Cell TransplantationAdultAgedCell MembraneCombined Modality TherapyFemaleHumansLeukemia, Myeloid, AcuteLymphoma, Large B-Cell, DiffuseLymphoproliferative DisordersMaleMiddle AgedMultiple MyelomaPatient SafetyPeptidesRadiometry177Lu-pentixather90Y-pentixatherCXCR4 protein, humanPeptidesReceptors, CXCR4chemokine receptor CXCR4endoradiotherapyleukemialymphomamyeloma

Identifiers

PMID30850502
PMCPMC6785788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.