Evidence map›Paper›PMID 30850413›Full record

ArticleBMJ open2019

Performance of commercial tests for molecular detection of Shiga toxin-producing

Gillian A M Tarr, Chu Yang Lin, Diane Lorenzetti, Linda Chui, Phillip I Tarr, Lisa Hartling, Ben Vandermeer, Stephen B Freedman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Constipation and hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gillian A M TarrDepartment of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Chu Yang LinFaculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Diane LorenzettiDepartment of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-8423-3458
Linda ChuiMicrobiology Section, Provincial Laboratory for Public Health-Alberta Public Laboratories, Edmonton, Alberta, Canada.
Phillip I TarrDepartment of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Lisa HartlingDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Ben VandermeerDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Stephen B FreedmanSections of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatrics, Alberta Children's Hospital and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRapid detection of Shiga toxin-producing METHODS AND ANALYSIS: The following databases will be searched employing a standardised search strategy: Medline, Embase, Cochrane CENTRAL Register of Controlled Trials, Cochrane Database of Systematic Reviews, PubMed, Scopus and Web of Science. Grey literature will be searched under advice from a medical librarian. Independent reviewers will screen titles, abstracts and full texts of retrieved studies for relevant studies. Data will be extracted independently by two reviewers, using a piloted template. Quality Assessment of Diagnostic Accuracy Studies-2 will be employed to assess the risk of bias of individual studies, and the quality of evidence will be assessed with the Grading of Recommendations Assessment, Development and Evaluation approach. A bivariate random-effects model will be used to meta-analyse the sensitivity and specificity of commercial STEC diagnostic tests, and a hierarchical summary receiver operator characteristic curve will be constructed. Studies of single test accuracy of EIA and NAATs and studies of comparative accuracy will be analysed separately. ETHICS AND DISSEMINATION: Ethics approval was not required for this systematic review and meta-analysis. Findings will be disseminated in conferences, through a peer-reviewed journal and via personal interactions with relevant stakeholders. PROSPERO REGISTRATION NUMBER: CRD42018099119.

Indexed as

Escherichia coli InfectionsImmunoenzyme TechniquesNucleic Acid Amplification TechniquesShiga-Toxigenic Escherichia coliCommerceEarly DiagnosisHumansMeta-Analysis as TopicSensitivity and SpecificitySystematic Reviews as Topicdiagnosticsensitivityshiga toxin-producing escherichia colispecificitytesting

Identifiers

PMID30850413
PMCPMC6430022

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.