Evidence map›Paper›PMID 30850412›Full record

ArticleBMJ open2019

Towards a decision support tool for intensive care discharge: machine learning algorithm development using electronic healthcare data from MIMIC-III and Bristol, UK.

Christopher J McWilliams, Daniel J Lawson, Raul Santos-Rodriguez, Iain D Gilchrist, Alan Champneys, Timothy H Gould, Mathew Jc Thomas, Christopher P Bourdeaux

Abstract read
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Observational
  2. Article
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  4. Review
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  7. Review
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  9. Explainable hierarchical clustering for patient subtyping and risk prediction.Experimental biology and medicine (Maywood, N.J.) · 2023
    Article
  10. Article
  11. Review
  12. Article
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  14. Artificial intelligence and machine learning in precision and genomic medicine.Medical oncology (Northwood, London, England) · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Optimization of critical care pharmacy clinical services: A gap analysis approach.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christopher J McWilliamsEngineering Mathematics, University of Bristol, Bristol, UK.
Daniel J LawsonIntegrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.
Raul Santos-RodriguezEngineering Mathematics, University of Bristol, Bristol, UK.
Iain D GilchristDepartment of Experimental Psychology, University of Bristol, Bristol, UK.
Alan ChampneysEngineering Mathematics, University of Bristol, Bristol, UK.
Timothy H GouldIntensive Care Unit, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
Mathew Jc ThomasIntensive Care Unit, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
Christopher P BourdeauxIntensive Care Unit, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Funding

Wellcome TrustWellcome Trust WT104125MA
6 · The paper itself

Abstract

objectiveThe primary objective is to develop an automated method for detecting patients that are ready for discharge from intensive care.

designWe used two datasets of routinely collected patient data to test and improve on a set of previously proposed discharge criteria.

settingBristol Royal Infirmary general intensive care unit (GICU). PATIENTS: Two cohorts derived from historical datasets: 1870 intensive care patients from GICU in Bristol, and 7592 from Medical Information Mart for Intensive Care (MIMIC)-III.

resultsIn both cohorts few successfully discharged patients met all of the discharge criteria. Both a random forest and a logistic classifier, trained using multiple-source cross-validation, demonstrated improved performance over the original criteria and generalised well between the cohorts. The classifiers showed good agreement on which features were most predictive of readiness-for-discharge, and these were generally consistent with clinical experience. By weighting the discharge criteria according to feature importance from the logistic model we showed improved performance over the original criteria, while retaining good interpretability.

conclusionsOur findings indicate the feasibility of the proposed approach to ready-for-discharge classification, which could complement other risk models of specific adverse outcomes in a future decision support system. Avenues for improvement to produce a clinically useful tool are identified.

Indexed as

Decision Support TechniquesMachine LearningPatient DischargeAlgorithmsCritical CareElectronic Health RecordsEnglandFemaleHumansLength of StayMalePatient Readmissioncinical audithealth informaticsinformation technology

Identifiers

PMID30850412
PMCPMC6429919

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.