Evidence map›Paper›PMID 30850408›Full record

ReviewBMJ open2019

Top research priorities in liver and gallbladder disorders in the UK.

Kurinchi S Gurusamy, Martine Walmsley, Brian R Davidson, Claire Frier, Barry Fuller, Angela Madden, Steven Masson, Richard Morley, Ivana Safarik, Emmanuel A Tsochatzis and 13 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 11 pooled it
12.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 11 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 1 country.

Kurinchi S GurusamyDivision of Surgery and Interventional Science, University College London, London, UK.ORCID 0000-0002-0313-9134
Martine WalmsleyPSC Support, Oxfordshire, UK.
Brian R DavidsonDivision of Surgery and Interventional Science, University College London, London, UK.
Claire FrierHPB Surgery, Royal Free London NHS Foundation Trust, London, UK.
Barry FullerDivision of Surgery and Interventional Science, University College London, London, UK.
Angela MaddenNutrition and Dietetics, University of Hertfordshire, Hatfield, UK.
Steven MassonHepatology, Freeman Hospital, Newcastle upon Tyne, UK.
Richard MorleyCochrane Collaboration Consumer Network, London, UK.
Ivana SafarikCarolside Medical Centre, Clarkston, UK.
Emmanuel A TsochatzisUCL Institute for Liver and Digestive Health, University College London, London, UK.
Irfan AhmedSurgery, NHS Grampian, Aberdeen, UK.
Maxine CowlinPatient Representative, UK.
John F DillonHepatology and Gastroenterology, NHS Tayside, Dundee, UK.
Graham EllicottPatient Representative, UK.
Ahmed M ElsharkawyHepatology, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
Liz FarringtonHepatology, Royal Cornwall Hospitals NHS Trust, Truro, UK.
Anthony GlachanPatient Representative, UK.
Nagappan KumarHPB Surgery, University Hospital of Wales, Cardiff, UK.
E J MilnePatient Representative, UK.
Simon M RushbrookHepatology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Amanda SmithPharmacy, Queen Elizabeth Hospital, Birmingham, UK.
Lizzie StaffordHepatology, John Radcliffe Hospital, Oxford, UK.
Andrew YeomanHepatology, Royal Gwent Hospital, Newport, UK.
University College London · GBQueen Elizabeth Hospital Birmingham · GBCochrane · GBFreeman Hospital · GBJohn Radcliffe Hospital · GBNHS Grampian · GBNHS Tayside · GBNorfolk and Norwich University Hospitals NHS Foundation Trust · GBRoyal Cornwall Hospital Trust · GBRoyal Free London NHS Foundation Trust · GBRoyal Gwent Hospital · GBUniversity Hospital of Wales · GBUniversity of Hertfordshire · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThere is a mismatch between research questions considered important by patients, carers and healthcare professionals and the research performed in many fields of medicine. The non-alcohol-related liver and gallbladder disorders priority setting partnership was established to identify the top research priorities in the prevention, diagnostic and treatment of gallbladder disorders and liver disorders not covered by the James-Lind Alliance (JLA) alcohol-related liver disease priority setting partnership.

designThe methods broadly followed the principles of the JLA guidebook. The one major deviation from the JLA methodology was the final step of identifying priorities: instead of prioritisation by group discussions at a consensus workshop involving stakeholders, the prioritisation was achieved by a modified Delphi consensus process.

resultsA total of 428 unique valid diagnostic or treatment research questions were identified. A literature review established that none of these questions were considered 'answered' that is, high-quality systematic reviews suggest that further research is not required on the topic. The Delphi panel achieved consensus (at least 80% Delphi panel members agreed) that a research question was a top research priority for six questions. Four additional research questions with highest proportion of Delphi panel members ranking the question as highly important were added to constitute the top 10 research priorities.

conclusionsA priority setting process involving patients, carers and healthcare professionals has been used to identify the top 10priority areas for research related to liver and gallbladder disorders. Basic, translational, clinical and public health research are required to address these uncertainties.

Indexed as

Attitude of Health PersonnelGallbladder DiseasesLiver DiseasesBiomedical ResearchCooperative BehaviorHealth PrioritiesHumansQuality ImprovementStakeholder ParticipationUnited Kingdomchronic liver diseaseliver

Identifiers

PMID30850408
PMCPMC6429888
OpenAlexW2922171973

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.