Evidence map›Paper›PMID 30850334›Full record

ArticleMedical engineering & physics2019

The effect of articular geometry features identified using statistical shape modelling on knee biomechanics.

Allison L Clouthier, Colin R Smith, Michael F Vignos, Darryl G Thelen, Kevin J Deluzio, Michael J Rainbow

Abstract read
In one paragraph

Article in Medical engineering & physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Age-Dependent Susceptibility to Mechanical Unloading-Induced Femoral Morphological Changes and Patellar Instability in a Rat Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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  14. ShapeMed-Knee: A Dataset and Neural Shape Model Benchmark for Modeling 3D Femurs.medRxiv : the preprint server for health sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Allison L ClouthierDepartment of Mechanical and Materials Engineering, Queen's University, 130 Stuart St., McLaughlin Hall, Kingston, ON K7L 3N6, Canada. Electronic address: allison.clouthier@queensu.ca.
Colin R SmithDepartment of Mechanical Engineering, University of Wisconsin-Madison, 1513 University Ave, Madison, WI 53706, USA.
Michael F VignosDepartment of Mechanical Engineering, University of Wisconsin-Madison, 1513 University Ave, Madison, WI 53706, USA.
Darryl G ThelenDepartment of Mechanical Engineering, University of Wisconsin-Madison, 1513 University Ave, Madison, WI 53706, USA.
Kevin J DeluzioDepartment of Mechanical and Materials Engineering, Queen's University, 130 Stuart St., McLaughlin Hall, Kingston, ON K7L 3N6, Canada.
Michael J RainbowDepartment of Mechanical and Materials Engineering, Queen's University, 130 Stuart St., McLaughlin Hall, Kingston, ON K7L 3N6, Canada.

Funding

A Multi-Scale Modeling Construct of Knee Mechanics following ACL ReconstructionU01EB015410 · NIBIB · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI DHAHER, YASIN YOUSEF, THELEN, DARRYL G · 2013 to 2016
$2.0M
NIBIB NIH HHS U01 EB015410
6 · The paper itself

Abstract

Articular geometry in the knee varies widely among people which has implications for risk of injury and pathology. The goals of this work were to develop a framework to systematically vary geometry in a multibody knee model and to use this framework to investigate the effect of morphological features on dynamic knee kinematics and contact mechanics. A statistical shape model of the tibiofemoral and patellofemoral joints was created from magnetic resonance images of 14 asymptomatic knees. The shape model was then used to generate 37 unique multibody knee models based on -3 to +3 standard deviations of the scores for the first six principal components identified. Each multibody model was then incorporated into a lower extremity musculoskeletal model and the Concurrent Optimization of Muscle Activations and Kinematics (COMAK) routine was used to simulate knee mechanics for overground walking. Changes in articular geometry affected knee function, resulting in differences up to 17° in orientation, 8 mm in translation, 0.7 BW in contact force, and 2.0 MPa in mean cartilage contact pressure. Understanding the relationship between shape and function in a joint could provide insight into the mechanisms behind injury and pathology and the variability in response to treatment.

Indexed as

Mechanical PhenomenaModels, StatisticalBiomechanical PhenomenaCartilageFemaleFinite Element AnalysisHumansKnee JointMaleYoung AdultKnee kinematicsKnee mechanicsMusculoskeletal modelStatistical shape model

Identifiers

PMID30850334
PMCPMC6529205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.