Evidence map›Paper›PMID 30850233›Full record

ArticleCell host & microbe2019

Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models.

Jose J Limon, Jie Tang, Dalin Li, Andrea J Wolf, Kathrin S Michelsen, Vince Funari, Matthew Gargus, Christopher Nguyen, Purnima Sharma, Viviana I Maymi and 9 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05119712 (Terbinafine Treatment of Axial Spondyloarthropathy), which is not on this map. Cited by 290 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
290citing papers in PubMed, 1 pooled it
42.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05119712 early_phase1withdrawnnot on this mapstarted 2021, after this paper: background citation

Terbinafine Treatment of Axial Spondyloarthropathy

TypeinterventionalSponsorOregon Health and Science UniversityRan2021 to 2024Enrolled0ConditionsAnkylosing Spondylitis, Axial Spondyloarthritis, Psoriatic Spondylitis, Spondylitis Secondary to Inflammatory Bowel DiseaseArmsTerbinafine Tablets, Laboratory Testing
3 · Its place in the literature

Who cites it

290 citing papers in PubMed, 1 synthesis or guideline pooled it, 450 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Innate immune recognition ofInfection and immunity · 2026
    Article
  5. Article
  6. Observational
  7. Review
  8. Fungal Infections in Disorders of Inborn Errors of Immunity.Clinical reviews in allergy & immunology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. A Developmental Perspective on the Intestinal Microbiota in Crohn's Disease.International journal of molecular sciences · 2026
    Review
  18. Article
  19. Article
  20. Article

230 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Jose J LimonF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Jie TangGenomics Core, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Dalin LiF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Andrea J WolfF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Kathrin S MichelsenF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Vince FunariGenomics Core, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Matthew GargusF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Christopher NguyenF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Purnima SharmaF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Viviana I MaymiF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Iliyan D IlievDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Joseph H SkalskiF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Jordan BrownGenomics Core, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Carol LandersF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
James BornemanDepartment of Plant Pathology and Microbiology, University of California, Riverside, Riverside, CA 92521, USA.
Jonathan BraunDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Stephan R TarganF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Dermot P B McGovernF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
David M UnderhillF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: david.underhill@csmc.edu.
Cedars-Sinai Medical Center · USCornell University · USMayo Clinic · USUniversity of California, Los Angeles · USUniversity of California, Riverside · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1M
Host immunity to commensal gut fungiR01DK093426 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI UNDERHILL, DAVID M. · 2012 to 2021
$3.7M
Acquisition of a Scalable Storage Cluster for Data Intensive NIH ResearchS10OD016290 · OD · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI GIRKE, THOMAS · 2014 to 2014
$593k
NCATS NIH HHS UL1 TR001881NIDDK NIH HHS P01 DK046763NIDDK NIH HHS R01 DK093426NIH HHS S10 OD016290
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is characterized by alterations in the intestinal microbiota and altered immune responses to gut microbiota. Evidence is accumulating that IBD is influenced by not only commensal bacteria but also commensal fungi. We characterized fungi directly associated with the intestinal mucosa in healthy people and Crohn's disease patients and identified fungi specifically abundant in patients. One of these, the common skin resident fungus Malassezia restricta, is also linked to the presence of an IBD-associated polymorphism in the gene for CARD9, a signaling adaptor important for anti-fungal defense. M. restricta elicits innate inflammatory responses largely through CARD9 and is recognized by Crohn's disease patient anti-fungal antibodies. This yeast elicits strong inflammatory cytokine production from innate cells harboring the IBD-linked polymorphism in CARD9 and exacerbates colitis via CARD9 in mouse models of disease. Collectively, these results suggest that targeting specific commensal fungi may be a therapeutic strategy for IBD.

Indexed as

AnimalsCARD Signaling Adaptor ProteinsColitisCrohn DiseaseCytokinesDisease Models, AnimalGastrointestinal TractMalasseziaMiceCard9 protein, mouseCARD Signaling Adaptor ProteinsCytokinesCARD9Crohn diseasec-type lectinMalasseziamycobiome

Identifiers

PMID30850233
PMCPMC6417942
OpenAlexW2918402014

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.