ArticleBiological psychiatry2019
Resting-State Functional Connectivity and Psychotic-like Experiences in Childhood: Results From the Adolescent Brain Cognitive Development Study.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed.
- Eye movement abnormalities in autism spectrum disorder and prodromal psychosis: a review of overlaps and biomarkers.Frontiers in child and adolescent psychiatry · 2026Review
- Differences in Resting-State Functional Connectivity of Temperament-Based Profiles Among Youths With Attention-Deficit/Hyperactivity Disorder in the Adolescent Brain Cognitive Development Study.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Brain handedness associations depend on how and when handedness is measured.Scientific reports · 2025Article
- Cognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population.Molecular psychiatry · 2025Article
- Attention-mediated genetic influences on psychotic symptomatology in adolescence.Nature. Mental health · 2024Article
- Constructing and exploring neuroimaging projects: a survey from clinical practice to scientific research.Insights into imaging · 2024Review
- Size and Topography of the Brain's Functional Networks with Psychotic Experiences, Schizophrenia, and Bipolar Disorder.Biological psychiatry global open science · 2024Article
- Examining the Most Important Risk Factors for Predicting Youth Persistent and Distressing Psychotic-Like Experiences.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- High Systolic Blood Pressure of High-Income African American Children.Journal of racial and ethnic health disparities · 2024Article
- Psychosis superspectrum II: neurobiology, treatment, and implications.Molecular psychiatry · 2024Review
- A precision functional atlas of personalized network topography and probabilities.Nature neuroscience · 2024Article
- Sex differences in the functional network underpinnings of psychotic-like experiences in children.bioRxiv : the preprint server for biology · 2024Article
- The link between residential stability and youth substance use: Role of stressful life events and behavioral problems.Journal of medicine, surgery, and public health · 2024Article
- Cognitive and Psychiatric Relevance of Dynamic Functional Connectivity States in a Large (N>10,000) Children Population.Research square · 2024Article
- Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events.Journal of mental health & clinical psychology · 2024Article
- Strengthening associations between psychotic like experiences and suicidal ideation and behavior across middle childhood and early adolescence.Psychological medicine · 2023Article
- Resting-State Functional Connectivity Explained Psychotic-like Experiences in the General Population and Partially Generalized to Patients and Relatives.Biological psychiatry global open science · 2023Article
- Associations with youth psychotic-like experiences over time: Evidence for trans-symptom and specific cognitive and neural risk factors.Journal of psychopathology and clinical science · 2023Article
- Characterizing different cognitive and neurobiological profiles in a community sample of children using a non-parametric approach: An fMRI study.Developmental cognitive neuroscience · 2023Article
- Cerebellar Functional Dysconnectivity in Drug-Naïve Patients With First-Episode Schizophrenia.Schizophrenia bulletin · 2023Article
Corrections and comments
- Erratum issuedErratum.2019
Authors and funding
4 authors.
Funding
Abstract
backgroundPsychotic-like experiences (PLEs) during childhood are associated with greater risk of developing a psychotic disorder (and other mental disorders), highlighting the importance of identifying neural correlates of childhood PLEs. Three major cortical networks-the cingulo-opercular network (CON), default mode network (DMN), and frontoparietal network-are consistently implicated in psychosis and PLEs in adults. However, it is unclear whether variation in functional connectivity is associated with PLEs in school-aged children.
methodsUsing hierarchical linear models, we examined the relationships between childhood PLEs and resting-state functional connectivity of the CON, DMN, and frontoparietal network, as well as the other networks, using an a priori network parcellation, using data from 9- to 11-year-olds (n = 3434) in the ABCD (Adolescent Brain Cognitive Development) study. We examined within-network, between-network, and subcortical connectivity.
resultsDecreased CON and DMN connectivity, as well as cinguloparietal (CPAR) network connectivity, were associated with greater PLEs, even after accounting for family history of psychotic disorders, internalizing symptoms, and cognitive performance. Decreased DMN connectivity was more strongly associated with increased delusional ideation, whereas decreased CON connectivity was more strongly associated with increased perceptual distortions. Increased CON-cerebellar and decreased CPAR-cerebellar connectivity were also associated with increased PLEs, and CPAR-cerebellar connectivity was more strongly associated with increased perceptual distortions.
conclusionsConsistent with hypotheses about the dimensionality of psychosis, our results provide novel evidence that neural correlates of PLEs, such as reduced functional connectivity of higher-order cognitive networks, are present even in school-aged children. The results provide further validation for continuity of PLEs across the life span.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.