ArticleBMC genomics2019
Genome-wide methylation is modified by caloric restriction in Daphnia magna.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Effects of RNAi-by-feeding on DNA methyltransferases inEnvironmental epigenetics · 2026Article
- DNA Methylation Patterns Provide Insights into the Epigenetic Regulation of Intersex Formation in the Chinese Mitten Crab (International journal of molecular sciences · 2025Article
- Maternal effects in the model system Daphnia: the ecological past meets the epigenetic future.Heredity · 2025Review
- Dietary restriction in senolysis and prevention and treatment of disease.Critical reviews in food science and nutrition · 2024Review
- Integrated Analysis of DNA Methylome and Transcriptome Reveals Epigenetic Regulation of Cold Tolerance inInternational journal of molecular sciences · 2023Article
- An In Vivo Whole-Transcriptomic Approach to Assess Developmental and Reproductive Impairments Caused by Flumequine inInternational journal of molecular sciences · 2023Article
- How can we modulate aging through nutrition and physical exercise? An epigenetic approach.Aging · 2023Review
- Intestinal microbiota: a new perspective on delaying aging?Frontiers in microbiology · 2023Review
- Long term environmental variability modulates the epigenetics of maternal traits of kelp crabs in the coast of Chile.Scientific reports · 2022Article
- The Less We Eat, the Longer We Live: Can Caloric Restriction Help Us Become Centenarians?International journal of molecular sciences · 2022Review
- Daphnia magna egg piRNA cluster expression profiles change as mothers age.BMC genomics · 2022Article
- Food deprivation exposes sex-specific trade-offs between stress tolerance and life span in the copepodEcology and evolution · 2022Article
- DNMT3.1 controls trade-offs between growth, reproduction, and life span under starved conditions in Daphnia magna.Scientific reports · 2021Article
- DNA methylation differs extensively between strains of the same geographical origin and changes with age in Daphnia magna.Epigenetics & chromatin · 2021Article
- Epigenetic Regulation by Dietary Restriction: Part II.Conditioning medicine · 2019Article
- Epigenetic, transcriptional and phenotypic responses in two generations ofEnvironmental epigenetics · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe degradation of epigenetic control with age is associated with progressive diseases of ageing, including cancers, immunodeficiency and diabetes. Reduced caloric intake slows the effects of ageing and age-related disease in vertebrates and invertebrates, a process potentially mediated by the impact of caloric restriction on epigenetic factors such as DNA methylation. We used whole genome bisulphite sequencing to study how DNA methylation patterns change with diet in a small invertebrate, the crustacean Daphnia magna. Daphnia show the classic response of longer life under caloric restriction (CR), and they reproduce clonally, which permits the study of epigenetic changes in the absence of genetic variation.
resultsGlobal cytosine followed by guanine (CpG) methylation was 0.7-0.9%, and there was no difference in overall methylation levels between normal and calorie restricted replicates. However, 333 differentially methylated regions (DMRs) were evident between the normally fed and CR replicates post-filtering. Of these 65% were hypomethylated in the CR group, and 35% were hypermethylated in the CR group.
conclusionsOur results demonstrate an effect of CR on the genome-wide methylation profile. This adds to a growing body of research in Daphnia magna that demonstrate an epigenomic response to environmental stimuli. Specifically, gene Ontology (GO) term enrichment of genes associated with hyper and hypo-methylated DMRs showed significant enrichment for methylation and acyl-CoA dehydrogenase activity, which are linked to current understanding of their roles in CR in invertebrate model organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.