Evidence map›Paper›PMID 30849725›Full record

ArticleBiosensors & bioelectronics2019

Facile fabrication of flexible glutamate biosensor using direct writing of platinum nanoparticle-based nanocomposite ink.

Tran N H Nguyen, James K Nolan, Hyunsu Park, Stephanie Lam, Mara Fattah, Jessica C Page, Hang-Eun Joe, Martin B G Jun, Hyungwoo Lee, Sang Joon Kim and 2 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 93 citations in OpenAlex.

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  8. Real-time in vivo thoracic spinal glutamate sensing during myocardial ischemia.American journal of physiology. Heart and circulatory physiology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Tran N H NguyenWeldon School of Biomedical Engineering, Birck Nanotechnology Center, Center for Implantable Device, Purdue University, West Lafayette, IN, USA.
James K NolanWeldon School of Biomedical Engineering, Birck Nanotechnology Center, Center for Implantable Device, Purdue University, West Lafayette, IN, USA.
Hyunsu ParkWeldon School of Biomedical Engineering, Birck Nanotechnology Center, Center for Implantable Device, Purdue University, West Lafayette, IN, USA.
Stephanie LamWeldon School of Biomedical Engineering, Birck Nanotechnology Center, Center for Implantable Device, Purdue University, West Lafayette, IN, USA.
Mara FattahSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Jessica C PageCollege of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Hang-Eun JoeSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Martin B G JunSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Hyungwoo LeeSamsung Advanced Institute of Technology, Suwon, South Korea.
Sang Joon KimSamsung Advanced Institute of Technology, Suwon, South Korea.
Riyi ShiWeldon School of Biomedical Engineering, Birck Nanotechnology Center, Center for Implantable Device, Purdue University, West Lafayette, IN, USA; College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Hyowon LeeWeldon School of Biomedical Engineering, Birck Nanotechnology Center, Center for Implantable Device, Purdue University, West Lafayette, IN, USA. Electronic address: hwlee@purdue.edu.
Purdue University West Lafayette · USSamsung (South Korea) · KR

Funding

Interdisciplinary Bioengineering Training in Diabetes ResearchT32DK101001 · NIDDK · PURDUE UNIVERSITY · PI EVANS-MOLINA, CARMELLA, VOYTIK-HARBIN, SHERRY L · 2013 to 2022
$1.6M
NIDDK NIH HHS T32 DK101001
6 · The paper itself

Abstract

Glutamate excitotoxicity is a pathology in which excessive glutamate can cause neuronal damage and degeneration. It has also been linked to secondary injury mechanisms in traumatic spinal cord injury. Conventional bioanalytical techniques used to characterize glutamate levels in vivo, such as microdialysis, have low spatiotemporal resolution, which has impeded our understanding of this dynamic event. In this study, we present an amperometric biosensor fabricated using a simple direct ink writing technique for the purpose of in vivo glutamate monitoring. The biosensor is fabricated by immobilizing glutamate oxidase on nanocomposite electrodes made of platinum nanoparticles, multi-walled carbon nanotubes, and a conductive polymer on a flexible substrate. The sensor is designed to measure extracellular dynamics of glutamate and other potential biomarkers during a traumatic spinal cord injury event. Here we demonstrate good sensitivity and selectivity of these rapidly prototyped implantable biosensors that can be inserted into a spinal cord and measure extracellular glutamate concentration. We show that our biosensors exhibit good flexibility, linear range, repeatability, and stability that are suitable for future in vivo evaluation.

Indexed as

Biosensing TechniquesElectrochemical TechniquesEnzymes, ImmobilizedGlucoseGlutamate DehydrogenaseGlutamic AcidHumansHydrogen PeroxideLimit of DetectionNanoparticlesNanotubes, CarbonPlatinumEnzymes, ImmobilizedGlucoseGlutamate DehydrogenaseGlutamic AcidHydrogen PeroxideNanotubes, CarbonPlatinumAdditive manufacturingBiosensorDirect ink writingGlutamateImplantableRapid prototypingSpinal cord injury

Identifiers

PMID30849725
PMCPMC7261495
OpenAlexW2912265956

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.