Evidence map›Paper›PMID 30849510›Full record

ArticleNeurobiology of disease2019

Beta synchrony in the cortico-basal ganglia network during regulation of force control on and off dopamine.

Petra Fischer, Alek Pogosyan, Alexander L Green, Tipu Z Aziz, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Michael Samuel, Keyoumars Ashkan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. From Motivation to Action: Action Cost Better Predicts Changes in Premovement Beta-Band Activity than Speed.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  8. Article
  9. Movement-related changes in pallidocortical synchrony differentiate action execution and observation in humans.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Article
  10. Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  11. Parkinsonian Beta Dynamics during Rest and Movement in the Dorsal Pallidum and Subthalamic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Petra FischerMedical Research Council Brain Network Dynamics Unit, University of Oxford, OX1 3TH Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK. Electronic address: petra.fischer@ndcn.ox.ac.uk.
Alek PogosyanMedical Research Council Brain Network Dynamics Unit, University of Oxford, OX1 3TH Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK.
Alexander L GreenNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK.
Tipu Z AzizNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK.
Jonathan HyamUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London Institute of Neurology, WC1N 3BG London, UK.
Thomas FoltynieUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London Institute of Neurology, WC1N 3BG London, UK.
Patricia LimousinUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London Institute of Neurology, WC1N 3BG London, UK.
Ludvic ZrinzoUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London Institute of Neurology, WC1N 3BG London, UK.
Michael SamuelDepartments of Neurology and Neurosurgery, King's College Hospital, King's College London, SE5 9RS London, UK.
Keyoumars AshkanDepartments of Neurology and Neurosurgery, King's College Hospital, King's College London, SE5 9RS London, UK.
Mauro Da LioDepartment of Industrial Engineering, Università degli Studi di Trento, via Sommarive, 9, 38123 Trento, Italy.
Mariolino De CeccoDepartment of Industrial Engineering, Università degli Studi di Trento, via Sommarive, 9, 38123 Trento, Italy.
Alberto FornaserDepartment of Industrial Engineering, Università degli Studi di Trento, via Sommarive, 9, 38123 Trento, Italy.
Peter BrownMedical Research Council Brain Network Dynamics Unit, University of Oxford, OX1 3TH Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK.
Huiling TanMedical Research Council Brain Network Dynamics Unit, University of Oxford, OX1 3TH Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK.

Funding

Medical Research Council MC_UU_12024/1Medical Research Council MR/P012272/1Parkinson's UK G-0811
6 · The paper itself

Abstract

Beta power suppression in the basal ganglia is stronger during movements that require high force levels and high movement effort but it has been difficult to dissociate the two. We recorded scalp EEG and basal ganglia local field potentials in Parkinson's disease patients (11 STN, 7 GPi) ON and OFF dopaminergic medication while they performed a visually-guided force matching task using a pen on a force-sensitive graphics tablet. Force adjustments were accompanied by beta power suppression irrespective of whether the force was increased or reduced. Before the adjustment was completed, beta activity returned. High beta power was specifically associated with slowing of the force adjustment. ON medication, the peak force rate was faster and cortico-basal ganglia beta phase coupling was more readily modulated. In particular, phase decoupling was stronger during faster adjustments. The results suggest that beta power in the basal ganglia does not covary with force per se, but rather with a related factor, the absolute force rate, or a more general concept of movement effort. The results also highlight that beta activity reappears during stabilization of isometric contractions, and that dopamine-related suppression of cortico-basal ganglia beta coupling is linked to faster force adjustments.

Indexed as

Action PotentialsAgedAntiparkinson AgentsBasal GangliaBeta RhythmCerebral CortexDeep Brain StimulationElectroencephalographyFemaleHumansLevodopaMaleMiddle AgedNerve NetParkinson DiseasePsychomotor PerformanceAntiparkinson AgentsLevodopaBeta couplingBeta oscillationsBeta powerCortico-basal ganglia couplingForce controlIsometric contraction

Identifiers

PMID30849510
PMCPMC6517271

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.