ArticleJournal of neuroscience methods2019
ReStore: A wireless peripheral nerve stimulation system.
Article in Journal of neuroscience methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- At-Home Delivery of Vagus Nerve Stimulation Paired With Task-Specific Training Improves Performance of High-Priority Activities in Persons With Chronic Spinal Cord Injury or Stroke.American journal of physical medicine & rehabilitation · 2026Trial
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- Implantation of a passive electrical neurostimulation device achieves inflammatory modulation in rodents.Communications biology · 2026Article
- Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces.Bioelectronic medicine · 2026Review
- Experimental Validation of a Battery-Free RFID-Powered Implantable Neural Sensor and Stimulator.Sensors (Basel, Switzerland) · 2026Article
- Clinical experience implanting a miniature externally powered vagus nerve stimulator.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- A closed loop fully automated wireless vagus nerve stimulation system.Scientific reports · 2025Article
- Toward Wireless Implantable Robotic Systems Driven by Magnetic Field for Personalized Therapy.Advanced robotics research · 2025Article
- Scaling of vagus nerve stimulation parameters does not achieve equivalent nerve responses across species.Bioelectronic medicine · 2025Article
- Advice for translational neuroscience: move deliberately and build things.Bioelectronic medicine · 2025Article
- Characterization of an Algorithm for Autonomous, Closed-Loop Neuromodulation During Motor Rehabilitation.Neurorehabilitation and neural repair · 2024Article
- A Sensory Feedback Neural Stimulator Prototype for Both Implantable and Wearable Applications.Micromachines · 2024Article
- Magnetoelectrics enables large power delivery to mm-sized wireless bioelectronics.Journal of applied physics · 2023Article
- Effects of Non-Invasive Neuromodulation of the Vagus Nerve for Management of Tinnitus: A Systematic Review with Meta-Analysis.Journal of clinical medicine · 2023Review
- Wireless and battery-free technologies for neuroengineering.Nature biomedical engineering · 2023Review
- Usage of RePlay as a Take-Home System to Support High-Repetition Motor Rehabilitation After Neurological Injury.Games for health journal · 2023Article
- Vagus nerve stimulation using a miniaturized wirelessly powered stimulator in pigs.Scientific reports · 2022Article
- Vagus Nerve Stimulation as a Treatment for Fear and Anxiety in Individuals with Autism Spectrum Disorder.Journal of psychiatry and brain science · 2022Article
- Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing.Journal of visualized experiments : JoVE · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe growing use of neuromodulation techniques to treat neurological disorders has motivated efforts to improve on the safety and reliability of implantable nerve stimulators. NEW
methodThe present study describes the ReStore system, a miniature, implantable wireless nerve stimulator system that has no battery or leads and is constructed using commercial components and processes. The implant can be programmed wirelessly to deliver charge-balanced, biphasic current pulses of varying amplitudes, pulse widths, frequencies, and train durations. Here, we describe bench and in vivo testing to evaluate the operational performance and efficacy of nerve recruitment. Additionally, we also provide results from a large-animal chronic active stimulation study assessing the long-term biocompatibility of the device.
resultsThe results show that the system can reliably deliver accurate stimulation pulses through a range of different loads. Tests of nerve recruitment demonstrate that the implant can effectively activate peripheral nerves, even after accelerated aging and post-chronic implantation. Biocompatibility and hermeticity tests provide an initial indication that the implant will be safe for use in humans. COMPARISON WITH EXISTING METHOD(S): Most commercially available nerve stimulators include a battery and wire leads which often require subsequent surgeries to address failures in these components. Though miniaturized battery-less stimulators have been prototyped in academic labs, they are often constructed using custom components and processes that hinder clinical translation.
conclusionsThe results from testing the performance and safety of the ReStore system establish its potential to advance the field of peripheral neuromodulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.