ArticleAmerican journal of ophthalmology2019
Projection-Resolved Optical Coherence Tomographic Angiography of Retinal Plexuses in Retinitis Pigmentosa.
Article in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Cystoid Macular Edema in Retinitis Pigmentosa: Pathophysiologic Insight Using Swept-Source OCT and Angiography.Ophthalmology science · 2026Article
- Widefield OCT angiography.Progress in retinal and eye research · 2025Review
- Flow and ischemic changes in retina and choroid across diabetic retinopathy spectrum: a SS-OCTA study.Eye (London, England) · 2025Observational
- Glaucomatous Focal Perfusion Loss in the Macula Measured by Optical Coherence Tomographic Angiography.American journal of ophthalmology · 2024Article
- Posterior segment findings in a patient with aAmerican journal of ophthalmology case reports · 2024Article
- Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023Review
- Quantification of microvascular change of retinal degeneration in Royal College of Surgeons rats using high-resolution spectral domain optical coherence tomography angiography.Journal of biomedical optics · 2023Article
- OCT angiography and its retinal biomarkers [Invited].Biomedical optics express · 2023Review
- Clinical Applications of Optical Coherence Tomography Angiography in Inherited Retinal Diseases: An Up-to-Date Review of the Literature.Journal of clinical medicine · 2023Review
- Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations.Investigative ophthalmology & visual science · 2022Article
- Superficial and Deep Macula Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.Journal of glaucoma · 2021Article
- Optical coherence tomography angiography findings in patients undergoing transcorneal electrical stimulation for treating retinitis pigmentosa.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Phenotypic Differences in aDiagnostics (Basel, Switzerland) · 2021Article
- Artifacts and artifact removal in optical coherence tomographic angiography.Quantitative imaging in medicine and surgery · 2021Review
- Prospective deep phenotyping of choroideremia patients using multimodal structure-function approaches.Eye (London, England) · 2021Article
- Near-infrared fundus autofluorescence alterations correlate with swept-source optical coherence tomography angiography findings in patients with retinitis pigmentosa.Scientific reports · 2021Article
- Outer Macular Microvascular Supply in Retinitis Pigmentosa Examined using Optical Coherence Tomography Angiography.Journal of ophthalmology · 2021Article
- Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography.Progress in retinal and eye research · 2021Review
- In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review.International journal of ophthalmology · 2021Review
- Choroidal vascular changes in retinitis pigmentosa patients detected by optical coherence tomography angiography.BMC ophthalmology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo use projection-resolved optical coherence tomographic angiography (PR-OCTA) to characterize the microvascular changes in 3 distinct retinal plexuses in retinitis pigmentosa (RP) patients.
designProspective cross-sectional study.
methodsA commercial 70-kHz spectral-domain optical coherence tomography (OCT) system was used to acquire 6-mm macular scans from RP patients and age-matched healthy participants at a tertiary academic center. Blood flow was detected using a commercial version of split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. The PR-OCTA algorithm was used to suppress projection artifacts and resolve microvasculature in 3 plexuses around the macula. Vessel density was calculated from en face OCTA of the parafoveal and perifoveal regions in each of the 3 plexuses, as well as the all-plexus inner retinal slab. Inner and outer retinal thicknesses were measured form structural OCT scans. Generalized estimating equations and Spearman's rank correlation statistical methods were used.
resultsForty-four eyes from 26 RP patients and 34 eyes from 26 healthy subjects were included. Significant reduction in vessel density was detected in the perifovea but not the parafovea of inner retinal slab of RP patients (P = .001 and P = .56, respectively) compared to controls. We also found deeper retinal plexuses (intermediate and deep capillary plexuses, ICP and DCP) were primarily damaged by RP, compared to superficial vascular complex (SVC). Significant thickening of the inner retina and thinning of the outer retina were also observed. Strong correlation was found between the vessel density in the perifoveal ICP and DCP and outer retinal thickness in RP patients with no history of cystoid macular edema.
conclusionsPR-OCTA enables the detection of microvascular changes in the perifoveal regions of the ICP and DCP in RP, with relative sparing of the SVC. OCT and OCTA parameters might be able to provide better understanding of the pathophysiology of the disease, as well as monitoring disease progression and the response to experimental treatments.
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