Evidence map›Paper›PMID 30849341›Full record

Trial reportAmerican journal of ophthalmology2019

Effect of Graft Attachment Status and Intraocular Pressure on Descemet Stripping Automated Endothelial Keratoplasty Outcomes in the Cornea Preservation Time Study.

Anthony J Aldave, Mark A Terry, Loretta B Szczotka-Flynn, Wendi Liang, Allison R Ayala, Maureen G Maguire, Robert C O'Brien, Beth Ann Benetz, John E Bokosky, Steven P Dunn and 21 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
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  9. DMEK outcomes using nondiabetic grafts for recipients with diabetes mellitus.American journal of ophthalmology case reports · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 16 institutions in 1 country.

Anthony J AldaveStein Eye Institute, University of California, Los Angeles, Los Angeles, California, USA.
Mark A TerryDevers Eye Institute, Portland, Oregon, USA.
Loretta B Szczotka-FlynnCase Western Reserve University Department of Ophthalmology and Visual Sciences, University Hospitals Eye Institute, and the Cornea Image Analysis Reading Center, Cleveland, Ohio, USA.
Wendi LiangJaeb Center for Health Research, Tampa, Florida, USA.
Allison R AyalaJaeb Center for Health Research, Tampa, Florida, USA.
Maureen G MaguireCenter for Preventive Ophthalmology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Robert C O'BrienJaeb Center for Health Research, Tampa, Florida, USA.
Beth Ann BenetzCase Western Reserve University Department of Ophthalmology and Visual Sciences, University Hospitals Eye Institute, and the Cornea Image Analysis Reading Center, Cleveland, Ohio, USA.
John E BokoskyEye Care of San Diego, San Diego, California, USA.
Steven P DunnMichigan Cornea Consultants, P.C., Southfield, Michigan, USA.
Thomas E GilletteEye Associates Northwest, Seattle, Washington, USA.
Kristin M HammersmithWills Eye Hospital, Philadelphia, Pennsylvania, USA.
David R HardtenMinnesota Eye Consultants, Bloomington, Minnesota, USA.
Bennie H JengUniversity of California, San Francisco, San Francisco, California, USA.
Marc F JonesNortheast Ohio Eye Surgeons, Kent, Ohio, USA.
Richard L LindstromMinnesota Eye Consultants, Bloomington, Minnesota, USA.
Kenneth J MaverickFocal Point Vision, San Antonio, Texas, USA.
Verinder S NirankariEye Consultants of Maryland, Owings Mills, Maryland, USA.
Matthew S OlivaMedical Eye Center, Medford, Oregon, USA.
Irving M RaberOphthalmic Partners of PA, P.C., Bala Cynwyd, Pennsylvania, USA.
Christopher J RapuanoWills Eye Hospital, Philadelphia, Pennsylvania, USA.
George O D RosenwasserCentral Pennsylvania Eye Institute, Hershey, Pennsylvania, USA.
Kevin W RossEversight, Ann Arbor, Michigan, USA.
John W SeedorNew York Eye and Ear Infirmary, New York, New York, USA.
Neda ShamieKeck Medical Center of University of Southern California, Ophthalmology, Los Angeles, California, USA.
Christopher G StoegerLions VisionGift, Portland, Oregon, USA.
Shachar TauberMercy-St. John's Clinic, Springfield, Missouri, USA.
Woodford S Van MeterUniversity of Kentucky Department of Ophthalmology, Lexington, Kentucky, USA.
David D VerdierVerdier Eye Center, Grand Rapids, Michigan, USA.
Jonathan H LassCase Western Reserve University Department of Ophthalmology and Visual Sciences, University Hospitals Eye Institute, and the Cornea Image Analysis Reading Center, Cleveland, Ohio, USA. Electronic address: jlasscornea@gmail.com.
Cornea Preservation Time Study Group
Case Western Reserve University · USJaeb Center for Health Research · USMinnesota Eye Consultants · USNorthwest Eye Surgeons · USWills Eye Hospital · USEye Care Associates · USHershey (United States) · USLegacy Health · USMinnesota Lions Eye Bank · USNew York Eye and Ear Infirmary · USSisters of Mercy Health System · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Kentucky · USUniversity of Pennsylvania · USUniversity of Southern California · US

Funding

Effect of Corneal Preservation Time on Long-Term Graft Success (CPTS)U10EY020797 · NEI · JAEB CENTER FOR HEALTH RESEARCH, INC. · PI AYALA, ALLISON RENEE · 2011 to 2016
$7.5M
Effect of Corneal Preservation Time on Long-Term Graft Success - Study ChairU10EY020798 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI LASS, JONATHAN H · 2011 to 2015
$5.6M
NEI NIH HHS U10 EY020797NEI NIH HHS U10 EY020798
6 · The paper itself

Abstract

purposeTo examine the association of donor, recipient, and operative factors on graft dislocation after Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS) as well as the effects of graft dislocation and elevated IOP on graft success and endothelial cell density (ECD) 3 years postoperatively.

designCohort study within a multi-center, double-masked, randomized clinical trial.

methods1090 individuals (1330 study eyes), median age 70 years, undergoing DSAEK for Fuchs endothelial corneal dystrophy (94% of eyes) or pseudophakic or aphakic corneal edema (6% of eyes). Recipient eyes receiving donor corneal tissue randomized by preservation time (PT) of 0-7 days (N = 675) or 8-14 days (N = 655) were monitored for early or late graft failure through 3 years. Donor, recipient, operative, and postoperative parameters were recorded including graft dislocation (GD), partial detachment, and pre- and post-operative IOP. Pre- and postoperative central donor ECD were determined by a central image analysis reading center. Proportional hazards, mixed effects, and logistic regression models estimated risk ratios and (99% confidence intervals).

resultsThree independent predictive factors for GD were identified: a history of donor diabetes (odds ratio [OR]: 2.29 [1.30, 4.02]), increased pre-lamellar dissection central corneal thickness (OR: 1.13 [1.01, 1.27] per 25µ increase), and operative complications (OR: 2.97 [1.24, 7.11]). Among 104 (8%) eyes with GD, 30 (28.9%) developed primary donor or early failure and 5 (4.8%) developed late failure vs. 15 (1.2%; P < .001) and 29 (2.4%; P = .04), respectively, of 1226 eyes without GD. 24 (2%) of 1330 study eyes had early acutely elevated postoperative IOP that was associated with a higher risk of graft failure through 3 years (hazard ratio: 3.42 [1.01, 11.53]), but not with a lower mean 3-year ECD (mean difference 61 (-479, 601) cells/mm

conclusionsDonor diabetes, increased donor corneal thickness, and intraoperative complications were associated with an increased risk of GD. Early acutely elevated postoperative IOP and GD significantly increased the risk for graft failure following DSAEK.

Indexed as

AdultAgedAged, 80 and overCell CountCorneaCorneal EdemaDescemet Stripping Endothelial KeratoplastyDouble-Blind MethodFemaleFollow-Up StudiesFuchs' Endothelial DystrophyGraft RejectionGraft SurvivalHumansIntraocular PressureMale

Identifiers

PMID30849341
PMCPMC6612575
OpenAlexW2921592956

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.