ArticleJournal of nutrition in gerontology and geriatrics
Long-Term Effects of Randomization to a Weight Loss Intervention in Older Adults: A Pilot Study.
Article in Journal of nutrition in gerontology and geriatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- The Role of Physical Activity in Long-term Weight Loss: 36-month Results From a Randomized Controlled Trial.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Trial
- Changes in Body Weight and Knee Pain in Adults With Knee Osteoarthritis Three-and-a-Half Years After Completing Diet and Exercise Interventions: Follow-Up Study for a Single-Blind, Single-Center, Randomized Controlled Trial.Arthritis care & research · 2022Trial
- The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act.Obesity (Silver Spring, Md.) · 2025Review
- Long-term Changes in Body Composition and Exercise Capacity Following Calorie Restriction and Exercise Training in Older Patients with Obesity and Heart Failure With Preserved Ejection Fraction.Journal of cardiac failure · 2025Article
- Approach to the patient with controlled acromegaly and acromegalic arthropathy: clinical diagnosis and management.Pituitary · 2024Review
- A novel controlled metabolic accelerator for the treatment of obesity-related heart failure with preserved ejection fraction: Rationale and design of the Phase 2a HuMAIN trial.European journal of heart failure · 2024Article
- Nonpharmacological Strategies in Heart Failure with Preserved Ejection Fraction.Cardiology clinics · 2022Review
- Midpoint of energy intake, non-fasting time and cardiorespiratory fitness in heart failure with preserved ejection fraction and obesity.International journal of cardiology · 2022Article
- Obesity treatment: Weight loss versus increasing fitness and physical activity for reducing health risks.iScience · 2021Review
- Changes in mood and health-related quality of life in Look AHEAD 6 years after termination of the lifestyle intervention.Obesity (Silver Spring, Md.) · 2021Article
- Racial Differences and Temporal Obesity Trends in Heart Failure with Preserved Ejection Fraction.Journal of the American Geriatrics Society · 2021Article
- Prevention and Treatment of Heart Failure: We Want to Pump You Up.JACC. Cardiovascular imaging · 2021Article
- Insufficient Calorie Intake Worsens Post-Discharge Quality of Life and Increases Readmission Burden in Heart Failure.JACC. Heart failure · 2020Article
- Dietary weight-loss interventions for the management of obesity in older adults.Reviews in endocrine & metabolic disorders · 2020Review
- Prevention and Treatment of Sarcopenic Obesity in Women.Nutrients · 2019Review
- The role of diet and nutrition in heart failure: A state-of-the-art narrative review.Progress in cardiovascular diseasesReview
- Obesity in the Older Adult: Special Issue.Journal of nutrition in gerontology and geriatricsArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Randomized, controlled trials (RCTs) show intentional weight loss improves body composition and physical function in older adults; however, the long-term benefits (and risks) are unknown. We conducted a pilot study to assess the feasibility of recalling prior RCT participants to examine the long-term effects of intentional weight loss on body composition and physical function. A weighted, random sample of 60 older adults who were randomized to caloric restriction plus exercise (CR + EX) or exercise (EX) only in 5 prior RCTs (mean age at randomization, 67.3 years; 69% women, 80% white) were invited to participate. Follow-up was obtained on 89% (42 clinic visits, 10 phone interviews, 1 death) an average of 3.5 years (range, 2.2-5.8 years) after RCT completion. Despite greater weight, fat and lean mass loss during the RCT (mean difference in change (95% CI): -4.19 (-7.52, -0.86), -2.75 (-5.10, -0.40), and -2.32 (-3.69, -0.95) kg, respectively) in those randomized to CR + EX, long-term changes in weight (2.05 (-2.35, 6.45) kg) and body composition (1.80 (-1.56, 5.17) and 0.03 (-2.20, 2.26) kg for fat and lean mass, respectively) from baseline and physical function at long-term follow-up (mean difference in 400-m walk and SPPB (95% CI): 23.2 (-19.3, 65.6) sec and -0.03 (-1.02, 0.96) points, respectively) were similar in CR + EX and EX only. Although improvements in weight and body composition following intentional weight loss may not be sustained long-term, physical function does not appear to be negatively impacted. A larger study is needed to confirm these results.
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Registered trials
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