ArticlePloS one2019
Relationships between muscle mass, strength and regional bone mineral density in young men.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Population-specific equations of age-related maximum handgrip force: a comprehensive review.PeerJ · 2024Pooled it
- Association Between Muscular Strength and Bone Health from Children to Young Adults: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Trial
- From Molecular Pathways to Artificial Intelligence: Advancing the Understanding and Management of Osteosarcopenia.International journal of molecular sciences · 2026Review
- Muscle strength and power in young volleyball players: reference values and age group differences.BMC sports science, medicine & rehabilitation · 2026Article
- Testosterone status and bone mineral density in Finnish male endurance athletes: Baseline associations and 1-year follow-up.Physiological reports · 2026Article
- Toe Grasp Strength and Its Association with Muscle Mass and Calcaneal Bone Status in Young Adults: A Cross-Sectional Study.Journal of musculoskeletal & neuronal interactions · 2026Article
- Determinants of Bone Mineral Density in Postmenopausal Women: The Role of Lean and Fat Mass by Dual Energy X-Ray Absorptiometry Assessment.Journal of bone metabolism · 2025Article
- GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density.Genome biology · 2025Article
- Association Between Isokinetic Lower Extremity Muscle Strength and Bone Mineral Density in Elderly Women With and Without Osteoporosis: A Case-Control Study.Journal of chiropractic medicine · 2025Article
- GWAS-Informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density.bioRxiv : the preprint server for biology · 2024Article
- Physical fitness components are bone mineral density predictors in adulthood: cross-sectional study.BMC musculoskeletal disorders · 2024Article
- Bone health and body composition in transgender adults before gender-affirming hormonal therapy: data from the COMET study.Journal of endocrinological investigation · 2024Article
- Evaluation of functioning and associated factors in children and adolescents with osteogenesis imperfecta.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2024Article
- Fracture severity dependence of bone and muscle performance in patients following single or multiple vertebral fractures.Frontiers in endocrinology · 2024Article
- Adipose Tissue Denervation Blunted the Decrease in Bone Formation Promoted by Obesity in Rats.Nutrients · 2023Article
- The Relationship Between Muscular Strength, Jump Power, and Bone Health in Collegiate Distance Runners.International journal of exercise science · 2023Article
- The bone mineral density and isokinetic knee strength in amputee soccer players.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Thirty Obesity Myths, Misunderstandings, and/or Oversimplifications: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022.Obesity pillars · 2022Article
- A bi-directional Mendelian randomization study of the sarcopenia-related traits and osteoporosis.Aging · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough the relationship between body composition and bone mineral density (BMD) is well established, the relative contribution of appendicular lean mass (ALM) and fat mass (FM) to BMD has been rarely evaluated in young men.
methodsWe assessed 100 young men (age: 24.4±2.8 years, BMI: 23.4±2.81 kg/m2). Appendicular lean mass index (ALM/H2) (ALMI), fat mass index (FM/ H2) (FMI), percentage of body fat, BMD at lumbar spine (LS), total hip (TH), femoral neck (FN) and whole body (WB) were measured using DXA. Muscle strength was evaluated by handgrip strength. Pearson's correlations and interactions between all variables were assessed using stepwise regression analyses.
resultsALM index (ALMI) was positively correlated with BMD at all sites (r = 0.62 for WB p<0.05, r = 0.54 for FN p<0.05, r = 0.64 for TH p<0.05, r = 0.56 for LS p<0.05) whereas FMI was not correlated to BMD values. Stepwise regression analyses showed that ALMI produced a significant and positive influence on BMD (β = 0.07 for WB p<0.001, β = 0.04 for FN p<0.001, β = 0.06 for TH p<0.001). Conversely, FMI was negatively associated with BMD at all sites (β = -0.02 for WB p<0.001, β = - 0.03 for FN p<0.001, β = - 0.03 for TH p<0.001, β = - 0.07 for LS p<0.001). Handgrip strength and BMDs were significantly and positively associated at all sites.
conclusionsOur data suggest that BMD was positively associated with ALMI while negatively with FMI. We confirm that ALMI is the strongest factor associated with BMD in a population of young men.
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