Evidence map›Paper›PMID 30849106›Full record

ArticlePloS one2019

NMD-12: A new machine-learning derived screening instrument to detect mild cognitive impairment and dementia.

Pai-Yi Chiu, Haipeng Tang, Cheng-Yu Wei, Chaoyang Zhang, Guang-Uei Hung, Weihua Zhou

Abstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Artificial Intelligence and Technology Collaboratories: Innovating aging research and Alzheimer's care.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  3. Article
  4. Article
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  6. Applications of artificial intelligence in dementia research.Cambridge prisms. Precision medicine · 2023
    Review
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  18. Analyze Informant-Based Questionnaire for The Early Diagnosis of Senile Dementia Using Deep Learning.IEEE journal of translational engineering in health and medicine · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pai-Yi ChiuDepartment of Neurology, Show Chwan Memorial Hospital, Changhua, Taiwan.
Haipeng TangSchool of Computing, University of Southern Mississippi, Hattiesburg, MS, United States of America.
Cheng-Yu WeiDepartment of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
Chaoyang ZhangSchool of Computing, University of Southern Mississippi, Hattiesburg, MS, United States of America.
Guang-Uei HungDepartment of Nuclear Medicine, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
Weihua ZhouSchool of Computing, University of Southern Mississippi, Hattiesburg, MS, United States of America.ORCID 0000-0002-6039-959X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUsing machine learning techniques, we developed a brief questionnaire to aid neurologists and neuropsychologists in the screening of mild cognitive impairment (MCI) and dementia.

methodsWith the reduction of the survey size as a goal of this research, feature selection based on information gain was performed to rank the contribution of the 45 items corresponding to patient responses to the specified questions. The most important items were used to build the optimal screening model based on the accuracy, practicality, and interpretability. The diagnostic accuracy for discriminating normal cognition (NC), MCI, very mild dementia (VMD) and dementia was validated in the test group.

resultsThe screening model (NMD-12) was constructed with the 12 items that were ranked the highest in feature selection. The receiver-operator characteristic (ROC) analysis showed that the area under the curve (AUC) in the test group was 0.94 for discriminating NC vs. MCI, 0.88 for MCI vs. VMD, 0.97 for MCI vs. dementia, and 0.96 for VMD vs. dementia, respectively. DISCUSSION: The NMD-12 model has been developed and validated in this study. It provides healthcare professionals with a simple and practical screening tool which accurately differentiates NC, MCI, VMD, and dementia.

Indexed as

Machine LearningAdultAgedAged, 80 and overArea Under CurveCognitive DysfunctionDementiaDiagnosis, Computer-AssistedDiagnosis, DifferentialFemaleGeriatric AssessmentHumansMaleMass ScreeningMiddle AgedNeuropsychological Tests

Identifiers

PMID30849106
PMCPMC6407752

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.