ArticlePLoS genetics2019
Molecular and cellular modulators for multisensory integration in C. elegans.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Serotonergic Signaling GovernseNeuro · 2025Article
- Behavioral adjustment of C. elegans to mechanosensory loss requires intact mechanosensory neurons.PLoS biology · 2024Article
- Antagonistic regulation of salt and sugar chemotaxis plasticity by a single chemosensory neuron in Caenorhabditis elegans.PLoS genetics · 2023Article
- Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation.Nature aging · 2023Article
- TGF-β pathways in aging and immunity: lessons fromFrontiers in genetics · 2023Review
- Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Redundant neural circuits regulate olfactory integration.PLoS genetics · 2022Article
- Sex differences in decision-making: Identifying multisensory behavioral differences in males and hermaphrodites.microPublication biology · 2022Article
- Valuing what happens: a biogenic approach to valence and (potentially) affect.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Molecular Strategies for Intensity-Dependent Olfactory Processing inFrontiers in molecular neuroscience · 2021Article
- Variation between nematodes in a multi-sensory behavioral assay.microPublication biology · 2020Article
- Glutamatergic transmission regulates locomotory behavior on a food patch inmicroPublication biology · 2020Article
- What can a worm learn in a bacteria-rich habitat?Journal of neurogeneticsReview
- The Conscious Nematode: Exploring Hallmarks of Minimal Phenomenal Consciousness inInternational journal of psychological researchArticle
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Authors and funding
6 authors.
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Abstract
In the natural environment, animals often encounter multiple sensory cues that are simultaneously present. The nervous system integrates the relevant sensory information to generate behavioral responses that have adaptive values. However, the neuronal basis and the modulators that regulate integrated behavioral response to multiple sensory cues are not well defined. Here, we address this question using a behavioral decision in C. elegans when the animal is presented with an attractive food source together with a repulsive odorant. We identify specific sensory neurons, interneurons and neuromodulators that orchestrate the decision-making process, suggesting that various states and contexts may modulate the multisensory integration. Among these modulators, we characterize a new function of a conserved TGF-β pathway that regulates the integrated decision by inhibiting the signaling from a set of central neurons. Interestingly, we find that a common set of modulators, including the TGF-β pathway, regulate the integrated response to the pairing of different foods and repellents. Together, our results provide mechanistic insights into the modulatory signals regulating multisensory integration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.