ArticleEnvironmental health perspectives2019
Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children.
Article in Environmental health perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- The Association of Cadmium Exposure and Anthropometrics in School-Age Children: A Longitudinal Study.Biological trace element research · 2026Article
- Impact of Maternal Exposure to Trace Metal Mixtures on Bone Mineral Density in Children Aged 3-6: Results from the Guangxi Zhuang Birth Cohort, China.Biological trace element research · 2025Article
- Environmental Risk in American Indian Children, Including Cardiovascular and Hematologic Consequences of Cadmium Exposure: Possible Means of Mitigation.International journal of environmental research and public health · 2025Review
- As, Cd, Hg, and Pb Biological Concentrations and Anthropometry in Slovak Adolescents.Biological trace element research · 2025Article
- Exposure to toxic chemical elements (Pb, Cd, and Hg) and its association with sustained high blood pressure among secondary school attending adolescents in Northwestern Tanzania.Environmental research · 2025Article
- The Preventive Impact of Chokeberry (Nutrients · 2025Article
- Effect of Luteolin on cadmium-inhibited bone growth via suppressing osteoclastogenesis in laying chickens.Journal of animal science · 2025Article
- Arsenic exposure and increasedRedox biochemistry and chemistry · 2023Article
- Airborne levels of cadmium are correlated with urinary cadmium concentrations among young children living in the New York state city of Syracuse, USA.Environmental research · 2023Article
- Early Life Environmental Exposure to Cadmium, Lead, and Arsenic and Age at Menarche: A Longitudinal Mother-Child Cohort Study in Bangladesh.Environmental health perspectives · 2023Article
- Article
- Exposure to metal mixture and growth indicators at 4-5 years. A study in the INMA-Asturias cohort.Environmental research · 2022Article
- Proximity to major roads and the incidence of osteoporotic fractures in elderly women: The BONE study in Beijing.Frontiers in public health · 2022Article
- Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels.International journal of molecular sciences · 2021Review
- The endocrine disruptor cadmium: a new player in the pathophysiology of metabolic diseases.Journal of endocrinological investigation · 2021Review
- Lead exposure and indices of height and weight in Uruguayan urban school children, considering co-exposure to cadmium and arsenic, sex, iron status and dairy intake.Environmental research · 2021Article
- The Association Between Cadmium Exposure and Osteoporosis: A Longitudinal Study and Predictive Model in a Chinese Female Population.Frontiers in public health · 2021Article
- Implications for prenatal cadmium exposure and adverse health outcomes in adulthood.Toxicology and applied pharmacology · 2020Review
- The Protective Impact of Black Chokeberry Fruit Extract (Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundChronic cadmium exposure has been associated with osteotoxicity in adults, but little is known concerning its effects on early growth, which has been shown to be impaired by cadmium.
objectivesOur objective was to assess the impact of early-life cadmium exposure on bone-related biomarkers and anthropometry at 9 y of age.
methodsFor 504 children in a mother-child cohort in Bangladesh, cadmium exposure was assessed by concentrations in urine (U-Cd, long-term exposure) and erythrocytes (Ery-Cd, ongoing exposure) at 9 and 4.5 y of age, and in their mothers during pregnancy. Biomarkers of bone remodeling [urinary deoxypyridinoline (DPD), urinary calcium, plasma parathyroid hormone, osteocalcin, vitamin D3, insulin-like growth factor (IGF) 1, IGF binding protein 3, thyroid stimulating hormone] were measured at 9 y of age.
resultsIn multivariable-adjusted linear models, a doubling of concurrent U-Cd was associated with a mean increase in osteocalcin of [Formula: see text] (95% CI: 0.042, 5.9) and in urinary DPD of [Formula: see text] (95% CI: 12, 32). In a combined exposure model, a doubling of maternal Ery-Cd was associated with a mean increase in urinary DPD of [Formula: see text] (95% CI: [Formula: see text], 30). Stratifying the osteocalcin model by gender ([Formula: see text] 0.001), a doubling of concurrent U-Cd was associated with a mean decrease in osteocalcin of [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]) in boys and a mean increase of [Formula: see text] (95% CI: 5.4, 13) in girls. The same pattern was seen with U-Cd at 4.5 y of age ([Formula: see text] 0.016). Children's U-Cd and Ery-Cd, concurrent and at 4.5 y of age, were inversely associated with vitamin D3.
conclusionsChildhood cadmium exposure was associated with several bone-related biomarkers and some of the associations differed by gender. https://doi.org/10.1289/EHP3655.
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