Evidence map›Paper›PMID 30848565›Full record

ArticleStem cells translational medicine2019

Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34

Andres F Martinez, William M Miller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Inside-to-outside and back to the future of megakaryopoiesis.Research and practice in thrombosis and haemostasis · 2023
    Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andres F MartinezDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA.
William M MillerDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0003-0750-6314
Northwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Developing Capacity to Evaluate Training Programs via Development of Human, Institutional and Social CapitalT32GM008449 · NIGMS · NORTHWESTERN UNIVERSITY · PI LEONARD, JOSHUA NATHANIEL · 1993 to 2023
$7.8M
Generating Human Cord-Blood-Derived Functional Megakaryocytes and platelets.R01HL130760 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MAHMUD, NADIM, MILLER, WILLIAM M · 2015 to 2018
$1.7M
NCI NIH HHS P30 CA060553NHLBI NIH HHS R01 HL130760NIGMS NIH HHS T32 GM008449
6 · The paper itself

Abstract

Patients suffering from acute or sustained thrombocytopenia require platelet transfusions, which are entirely donor-based and limited by challenges related to storage and fluctuating supply. Developing cell-culture technologies will enable ex vivo and donor-independent platelet production. However, critical advancements are needed to improve scalability and increase megakaryocyte (Mk) culture productivity. To address these needs, we evaluated Mk production from mobilized peripheral blood CD34

Indexed as

Cell Culture TechniquesCell ProliferationAntigens, CD34Blood PlateletsHumansMegakaryocyte Progenitor CellsMegakaryocytesAntigens, CD34CD34+Cell cultureCellular therapyMegakaryocyteThrombopoiesis

Identifiers

PMID30848565
PMCPMC6591548
OpenAlexW2921694094

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.