Evidence map›Paper›PMID 30848474›Full record

ArticleNeurotoxicity research2019

Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD.

Jennifer R Mepham, Francis H Boon, Kelly A Foley, Donald P Cain, Derrick F MacFabe, Klaus-Peter Ossenkopp

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis.Translational research : the journal of laboratory and clinical medicine · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Propionate and Alzheimer's Disease.Frontiers in aging neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jennifer R MephamGraduate Program in Neuroscience, Western University, London, Ontario, Canada.
Francis H BoonThe Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.
Kelly A FoleyGraduate Program in Neuroscience, Western University, London, Ontario, Canada.
Donald P CainGraduate Program in Neuroscience, Western University, London, Ontario, Canada.
Derrick F MacFabeThe Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.
Klaus-Peter OssenkoppGraduate Program in Neuroscience, Western University, London, Ontario, Canada. ossenkop@uwo.ca.ORCID http://orcid.org/0000-0001-7391-3239
Western University · CA

Funding

Natural Sciences and Engineering Research Council of Canada R2195A01
6 · The paper itself

Abstract

Propionic acid (PPA) is a dietary short chain fatty acid and an enteric bacterial metabolite. Intracerebroventricular (ICV) infusions of PPA in rodents have been shown to produce behavioral changes similar to those seen in autism spectrum disorders (ASD), including perseveration. The effects of ICV infusions of PPA on spatial cognition were examined by giving rats infusions of either PPA (0.26 M, pH 7.4, 4 μl/infusion) or phosphate-buffered saline (PBS, 0.1 M) twice a day for 7 days. The rats were then tested in the Morris water maze (MWM) for acquisition of spatial learning. After a recovery period of 1 week of no treatment, the rats were then tested for reversal of spatial learning in the MWM. PPA-treated rats showed impaired spatial learning in the maze, relative to controls, as demonstrated by increased search latencies, fewer direct and circle swims, and more time spent in the periphery of the maze than PBS controls. After a recovery period of 1 week of no treatment, these animals exhibited normal spatial reversal learning indicating that the behavioral cognitive deficits caused by PPA seem to be reversible.

Indexed as

Disease Models, AnimalAnimalsAutism Spectrum DisorderBehavior, AnimalGastrointestinal MicrobiomeInfusions, IntraventricularMaleMotor ActivityPropionatesRats, Long-EvansSpatial LearningPropionatespropionic acidAnimal modelAutism spectrum disordersPerseverationRatShort chain fatty acidSpatial cognition

Identifiers

PMID30848474
OpenAlexW2922099849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.