Observational studyJapanese journal of ophthalmology2019
Efficacy of N95 amplitude of pattern electroretinogram measured from baseline to N95 trough in the traumatic optic neuropathy.
Observational study in Japanese journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate the utility of selected pattern electroretinogram (PERG) parameters-including N95 amplitude and N95/P50 ratio, and a BL-N95 amplitude-in the analysis of visual function(s) and for predicting changes in retinal ganglion cell structures in traumatic optic neuropathy. STUDY
designA retrospective, observational case series performed at a single center.
methodsForty-four eyes from 36 patients diagnosed with optic neuropathy were included. A BL-N95 amplitude was defined as the amplitude measured from baseline to the trough of N95. PERG and pattern visual evoked potential (pVEP) measures were acquired within 1 week after onset of optic neuropathies. To compare functional and anatomical changes, mean temporal peripapillary retinal nerve fiber layer (pRNFL) and average and minimum ganglion cell-inner plexiform layer (GC-IPL) thicknesses were measured using optical coherence tomography.
resultsThirty-six patients (20 men, 16 women; mean age 37.5 ± 17.6 years) were evaluated. The BL-N95 amplitude was significantly smaller than the N95 amplitude (1.01 ± 0.56 μV and 2.45 ± 1.02 μV, respectively; p < 0.0001). Both the N95 (r = - 0.38, p = 0.010) and BL-N95 r = - 0.32, p = 0.029) amplitudes were significantly correlated with visual acuity. Although P100 latency was not correlated with all PERG parameters, the N95 (r = 0.32, p = 0.032) and BL-N95 (r = 0.41, p = 0.005) amplitudes demonstrated a positive correlation with P100 amplitude in pVEP. PERG parameters, including the N95 and BL-N95 amplitudes, and N95/P50 ratio, were not correlated with pRNFL thickness in optical coherence tomography. Only the BL-N95 amplitude demonstrated a significant correlation with GC-IPL.
conclusionThe BL-N95 amplitude-measured from baseline to the trough of N95-was valuable in the analysis of visual function(s) and for predicting changes in retinal ganglion cell structures in traumatic optic neuropathy.
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