Evidence map›Paper›PMID 30848361›Full record

ArticleMedical microbiology and immunology2019

Persistent viral replication and the development of T-cell responses after intranasal infection by MCMV.

Shunchuan Zhang, Sofia Caldeira-Dantas, Corinne J Smith, Christopher M Snyder

Open access · greenAbstract read
In one paragraph

Article in Medical microbiology and immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity.International journal of molecular sciences · 2019
    Review
  13. Review
  14. Caspase-8 restricts antiviral CD8 T cell hyperaccumulation.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Shunchuan ZhangDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, 19107, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-0143-9034
Sofia Caldeira-DantasDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, 19107, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-5467-4663
Corinne J SmithDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, 19107, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6548-9802
Christopher M SnyderDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, 19107, Philadelphia, PA, USA. christopher.snyder@jefferson.edu.ORCID http://orcid.org/0000-0003-1370-7198
Thomas Jefferson University · US

Funding

Selection of inflationary and tissue-resident T cells during MCMV infectionR01AI106810 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SNYDER, CHRISTOPHER M · 2014 to 2018
$1.7M
Selection of inflationary and tissue-resident T cells during MCMV infectionR56AI106810 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SNYDER, CHRISTOPHER M · 2013 to 2013
$364k
National Institute of Allergy and Infectious Diseases AI106810NIAID NIH HHS R01 AI106810NIAID NIH HHS R56 AI106810
6 · The paper itself

Abstract

Natural transmission of cytomegalovirus (CMV) has been difficult to observe. However, recent work using the mouse model of murine (M)CMV demonstrated that MCMV initially infects the nasal mucosa after transmission from mothers to pups. We found that intranasal (i.n.) inoculation of C57BL/6J mice resulted in reliable recovery of replicating virus from the nasal mucosa as assessed by plaque assay. After i.n. inoculation, CD8

Indexed as

Virus ReplicationAnimalsCytomegalovirus InfectionsDisease Models, AnimalImmunity, CellularMice, Inbred C57BLMuromegalovirusNasal MucosaT-LymphocytesCytomegalovirusIntranasal infectionNasal mucosaTissue-resident memory T cells

Identifiers

PMID30848361
PMCPMC6635021
OpenAlexW2921117533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.