Evidence map›Paper›PMID 30848348›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2019

Histamine H4 receptor regulates Th2-cytokine profile through thymic stromal lymphopoietin in allergic rhinitis.

Wei Wei Wang, Yong Liang Pan, Hong Wei Yu, Bo Zhang, Sheng Wen Shao

Abstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Interleukin-17A up-regulates thymic stromal lymphopoietin production by nasal fibroblasts from patients with allergic rhinitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei Wei WangSchools of Medicine and Nursing Sciences, Huzhou University, No.759, East Second Ring Road, Huzhou, 313000, Zhejiang, China.
Yong Liang PanSchools of Medicine and Nursing Sciences, Huzhou University, No.759, East Second Ring Road, Huzhou, 313000, Zhejiang, China.
Hong Wei YuSchools of Medicine and Nursing Sciences, Huzhou University, No.759, East Second Ring Road, Huzhou, 313000, Zhejiang, China.
Bo ZhangSchools of Medicine and Nursing Sciences, Huzhou University, No.759, East Second Ring Road, Huzhou, 313000, Zhejiang, China.
Sheng Wen ShaoSchools of Medicine and Nursing Sciences, Huzhou University, No.759, East Second Ring Road, Huzhou, 313000, Zhejiang, China. shaoswzhejiang@163.com.ORCID http://orcid.org/0000-0002-1792-4803
Huzhou University · CN

Funding

National Natural Science Foundation of China No.31672295Natural Science Foundation of Huzhou, China No.2015YZ02Public Welfare Technology Application Research Project of Zhejiang Province, China No.2017C37146
6 · The paper itself

Abstract

purposeEpithelial thymic stromal lymphopoietin (TSLP) promotes Th2 inflammatory responses through induction of OX40 ligand (OX40L) on dendritic cells in allergic rhinitis (AR). Emerging evidence supports the important role of histamine H4 receptor (H4R) in allergic inflammation. This study aimed to investigate the effects of H4R in Th2-cytokine profile mediated by TSLP in AR.

methodsHuman nasal epithelial cells (HNECs) from AR patients were stimulated with histamine in the presence or absence of H4R agonist (4-methylhistamine, 4-MH) and antagonist (NJ7777120, JNJ) or H1R agonist (2-pyridylethylamine). TSLP protein was measured by Western blotting and ELISA. To further elucidate the role of H4R in the in vivo situation of experimental AR, rats were sensitized and treated with JNJ or 4-MH. TSLP and OX40 ligand (OX40L) in the nasal mucosa were assayed by Western blotting. Th2 cytokines including interleukin-4, 5 and 13 in nasal lavage fluids were detected by ELISA.

resultsHistamine alone did not induce TSLP production by HNECs. The pre-incubation with 4-MH prior to histamine promoted TSLP expression, which was inhibited by the stimulation with JNJ prior to histamine and 4-MH. The pre-incubation with 2-pyridylethylamine before histamine stimulation had no impact on TSLP production. In AR rats, the levels of TSLP and OX40L protein were increased as well as Th2 cytokines, which was further up-regulated by 4-MH treatment, while JNJ treatment attenuated these effects.

conclusionsH4R activation induced TSLP production by HNECs, which up-regulated OX40L expression in the nasal mucosa of sensitized rats. These factors promoted Th2-cytokine profile in AR.

Indexed as

OX40 LigandReceptors, Histamine H4Rhinitis, AllergicTh2 CellsAnimalsCytokinesDendritic CellsHistamine AgentsHumansInflammationNasal MucosaRatsThymic Stromal LymphopoietinUp-RegulationCytokinesHistamine AgentsOX40 LigandReceptors, Histamine H4Thymic Stromal LymphopoietinAllergic rhinitisHistamine H4 receptorHuman nasal epithelial cellsOX40 ligandTh2 immune responseThymic stromal lymphopoietin

Identifiers

PMID30848348
OpenAlexW2921804381

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.