Evidence map›Paper›PMID 30848313›Full record

ArticleMedizinische Klinik, Intensivmedizin und Notfallmedizin2020

[Meningococcal sepsis without cerebrospinal fluid abnormalities under treatment with eculizumab].

Madlen Jentzsch, Sebastian Schwind, Vladan Vucinic, Sebastian Wendt, Catalina-Suzana Stingu, Dietger Niederwieser, Lorenz Weidhase

Abstract read
PubMed Publisher
In one paragraph

Article in Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Madlen JentzschMedizinische Klinik und Poliklinik I - Hämatologie und Zelltherapie, Internistische Onkologie, Hämostaseologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Sebastian SchwindMedizinische Klinik und Poliklinik I - Hämatologie und Zelltherapie, Internistische Onkologie, Hämostaseologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Vladan VucinicMedizinische Klinik und Poliklinik I - Hämatologie und Zelltherapie, Internistische Onkologie, Hämostaseologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Sebastian WendtInstitut für Mikrobiologie und Infektionsepidemiologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Catalina-Suzana StinguInstitut für Mikrobiologie und Infektionsepidemiologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Dietger NiederwieserMedizinische Klinik und Poliklinik I - Hämatologie und Zelltherapie, Internistische Onkologie, Hämostaseologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Lorenz WeidhaseInterdisziplinäre internistische Intensivstation, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland. lorenz.weidhase@medizin.uni-leipzig.de.
University Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections with Neisseriameningitidis are life-threatening conditions, generally presenting as meningitis. This case of a young woman who had a history of paroxysmal nocturnal hemoglobinuria under treatment with the complement inhibitor eculizumab had been presented with septic shock. While blood cultures were positive for Neisseria meningitidis, she showed no evidence for bacterial meningitis in the cerebrospinal fluid. This case shows that meningococcal sepsis without signs for bacterial meningitis despite repetitive vaccinations is possible in adults under eculizumab.

Indexed as

Hemoglobinuria, ParoxysmalShock, SepticAdultAntibodies, Monoclonal, HumanizedFemaleHumansMeningitis, MeningococcalMeningococcal InfectionsAntibodies, Monoclonal, HumanizedeculizumabEculizumabMeningitisNeisseria meningitidisParoxysmal nocturnal hemoglobinuriaSepsis

Identifiers

PMID30848313
OpenAlexW2922430918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.