ArticleSocial cognitive and affective neuroscience2019
Cortical morphometry of the five-factor model of personality: findings from the Human Connectome Project full sample.
Article in Social cognitive and affective neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Gray matter structures associated with neuroticism: A meta-analysis of whole-brain voxel-based morphometry studies.Human brain mapping · 2021Pooled it
- Alterations of Cortical Thickness in High Suicidality Patients with Panic Disorder and Their Relationship with Symptomatology and Treatment Response.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Association between neuroticism and brain-wide structural outcomes: Mediation by vascular and mental conditions.Psychological medicine · 2025Article
- When Brain Models Aren't Universal: Benchmarking of Ethnic Bias in MRI-Based Cognitive Prediction Across Modalities.bioRxiv : the preprint server for biology · 2025Article
- Mechanical Properties of the Cortex in Older Adults and Relationships With Personality Traits.Human brain mapping · 2025Article
- Identifying tripartite relationship among cortical thickness, neuroticism, and mood and anxiety disorders.Scientific reports · 2024Article
- Association between Reaction Times in the Joint Simon Task and Personality Traits.Brain sciences · 2023Article
- Conscientiousness associated with efficiency of the salience/ventral attention network: Replication in three samples using individualized parcellation.NeuroImage · 2023Article
- Premorbid Personality Traits as Risk Factors for Behavioral Addictions: A Systematic Review of a Vulnerability Hypothesis.Children (Basel, Switzerland) · 2023Review
- Personality traits modulate the neural responses to handwriting processing.Annals of the New York Academy of Sciences · 2022Article
- Empirical facts from search for replicable associations between cortical thickness and psychometric variables in healthy adults.Scientific reports · 2022Article
- Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism.Human brain mapping · 2022Article
- Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders.Scientific reports · 2022Observational
- Scan Once, Analyse Many: Using Large Open-Access Neuroimaging Datasets to Understand the Brain.Neuroinformatics · 2022Article
- "Nothing to see here": No structural brain differences as a function of thePersonality neuroscience · 2022Review
- Integration of structural brain networks is related to openness to experience: A diffusion MRI study with CSD-based tractography.Frontiers in neuroscience · 2022Article
- Neuroanatomical correlates of impulsive traits in children aged 9 to 10.Journal of abnormal psychology · 2020Article
- Little evidence for associations between the Big Five personality traits and variability in brain gray or white matter.NeuroImage · 2020Article
- Personality and local brain structure: Their shared genetic basis and reproducibility.NeuroImage · 2020Article
- From Description to Explanation: Integrating Across Multiple Levels of Analysis to Inform Neuroscientific Accounts of Dimensional Personality Pathology.Journal of personality disorders · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
This study is a replication of an existing large study (N = 507) on the surface-based morphometric correlates of five-factor model (FFM) personality traits. The same methods were used as the original study in another large sample drawn from the same population (N = 597) with results then being aggregated from both samples (N = 1104), providing the largest investigation into the neuroanatomical correlates of FFM personality traits to date. Clusters of association between brain morphometry and each FFM trait are reported. For neuroticism, agreeableness, openness and conscientiousness clusters of association were found in the dorsolateral prefrontal cortex for at least one morphometric index. Morphometry in various other regions was also associated with each personality trait. While some regions found in the original study were confirmed in the replication and full samples, others were not, highlighting the importance of replicating even high-quality, well-powered studies. Effect sizes were very similar in the replication and whole samples as those found in the original study. As a whole, the current results provide the strongest evidence to date on the neuroanatomical correlates of personality and highlights challenges in using this approach to understanding the neural correlates of personality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.