Evidence map›Paper›PMID 30848096›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2019

Protein supplementation improves lean body mass in physically active older adults: a randomized placebo-controlled trial.

Dominique S M Ten Haaf, Thijs M H Eijsvogels, Coen C W G Bongers, Astrid M H Horstman, Silvie Timmers, Lisette C P G M de Groot, Maria T E Hopman

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 9 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 9 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dominique S M Ten HaafDepartment of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands.ORCID 0000-0001-5095-8688
Thijs M H EijsvogelsDepartment of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands.ORCID 0000-0003-0747-4471
Coen C W G BongersDepartment of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands.ORCID 0000-0003-0055-5308
Astrid M H HorstmanFrieslandCampina, Amersfoort, The Netherlands.ORCID 0000-0003-4866-7368
Silvie TimmersDepartment of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands.ORCID 0000-0003-2852-5274
Lisette C P G M de GrootDivision of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.ORCID 0000-0003-2778-2789
Maria T E HopmanDepartment of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands.ORCID 0000-0001-9504-5452
Radboud University Nijmegen · NLFrieslandCampina (Netherlands) · NLWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn inadequate protein intake may offset the muscle protein synthetic response after physical activity, reducing the possible benefits of an active lifestyle for muscle mass. We examined the effects of 12 weeks of daily protein supplementation on lean body mass, muscle strength, and physical performance in physically active older adults with a low habitual protein intake (<1.0 g/kg/day).

methodsA randomized double-blinded controlled trial was performed among 116 physically active older adults [age 69 (interquartile range: 67-73) years, 82% male] who were training for a 4 day walking event of 30, 40, or 50 km/day. Participants were randomly allocated to either 31 g of milk protein or iso-caloric placebo supplementation for 12 weeks. Body composition (dual-energy X-ray absorptiometry), strength (isometric leg extension and grip strength), quadriceps contractile function, and physical performance [Short Physical Performance Battery, Timed Up-and-Go test, and cardiorespiratory fitness (Åstrand-Rhyming submaximal exercise test)] were measured at baseline and after 12 weeks. We assessed vitamin D status and markers of muscle damage and renal function in blood and urine samples before and after intervention.

resultsA larger increase in relative lean body mass was observed in the protein vs. placebo group (∆0.93 ± 1.22% vs. ∆0.44 ± 1.40%, P

conclusionsIn physically active older adults with relatively low habitual dietary protein consumption, an improvement in physical performance, an increase in lean body mass, and a decrease in fat mass were observed after walking exercise training. A larger increase in relative lean body mass and larger reduction in fat mass were observed in participants receiving 12 weeks of daily protein supplementation compared with controls, whereas this was not accompanied by differences in improvements between groups in muscle strength and physical performance.

Indexed as

Body CompositionDietary ProteinsDietary SupplementsExerciseGeriatric AssessmentNutrition AssessmentAgedAged, 80 and overBiomarkersDietFemaleHumansMaleMiddle AgedMuscle ContractionMuscle, SkeletalBiomarkersDietary ProteinsBody compositionElderlyMuscleProteinRandomized clinical trial

Identifiers

PMID30848096
PMCPMC6463466
OpenAlexW2921705899

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.